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FLASH GENE
Symbol RNASEH2A contributors: mct - updated : 17-01-2012
HGNC name ribonuclease H2, large subunit
HGNC id 18518
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminus is a eukaryotic adaptation for binding the two accessory subunits, with residues within it required for enzymatic activity and this C-terminal extension interacts with the RNASEH2C C terminus and both are necessary to form a stable, enzymatically active heterotrimer
  • HOMOLOGY
    Homologene
    FAMILY RNASE HII family, eukaryotic subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • endonuclease that specifically degrades the RNA of RNA- DNA hybrids
  • participating in DNA replication
  • may function to degrade RNA/DNA hybrids during cell death to avoid nucleic acid-mediated immune activation
  • ribonuclease H enzymes that specifically recognize RNA/DNA hybrids and hydrolyze the ribonucleotide-containing polynucleotide strand
  • SAMHD1, TREX1, and RNase H2 participate in a cellular nucleic acid metabolic pathway that overlaps the interferon-mediated innate antiviral and inflammatory responses
  • RNASEH1, RNASEH2A are necessary for the removal of RNA that is found in DNA
  • RNase H2 removes singly incorporated ribonucleoside 5-monophosphate (rNMP) residues in DNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component RNase H2 is a heterotrimeric complex of the RNase H2A, RNase H2B, and RNase H2C proteins that are all required for proper function and activity
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    manganese or magnesium
    protein
  • interfaces mostly with the RNase H2C subunit that is intricately interwoven with the RNase H2B subunit
  • C1QBP binds specifically to human RNASEH1, but not human RNASEH2A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AGS4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS