Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RIMBP2

contributors: npt/mct - updated : 15-02-2019

HGNC name	RIMS binding protein 2
HGNC id	30339

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q24.33      Physical location : 130.880.680 - 131.002.410
Synonym name	RIM binding protein 2
	cDNA sequence, expressed in brain, >100kDa
Synonym symbol(s)	KIAA0318, MGC15831, RBP2, RIM-BP2, PPP1R133

DNA

TYPE	functioning gene
STRUCTURE	320.23 kb     19 Exon(s)

text structure

contains several non-coding exons in its 5prime-UTR which could potentially be involved in translational regulatory processes

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015347 19 - 6335 NP_056162 116 1052 - 2007 17855024 NM_001351227 21 - 4942 NP_001338156 - 1123 - 2007 17855024 NM_001351229 22 - 4786 NP_001338158 - 1069 - 2007 17855024 NM_001351226 22 - 5032 NP_001338155 - 1123 - 2007 17855024 NM_001351230 22 - 6644 NP_001338159 - 1069 - 2007 17855024 NM_001351233 16 - 3904 NP_001338162 - 645 - 2007 17855024 NM_001351228 22 - 5005 NP_001338157 - 1123 - 2007 17855024 NM_001351231 22 - 6614 NP_001338160 - 1068 - 2007 17855024 NM_001351232 15 - 3336 NP_001338161 - 753 - 2007 17855024

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas           parathyroid         Nervous brain         Respiratory lung         Visual eye

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor Visual ganglion cell Visual rod photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three fibronectin type III-domains
	three Src homology 3 domains, of which the second Src homology 3 domain binds to RIMS, domain probably recognizing specific PXXP motifs

HOMOLOGY

Homologene

FAMILY

RIMBP family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	plasma membrane,junction
text	synaptic junction
	occuring postsynaptically in dendrites and cell bodies

basic FUNCTION	playing a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B
	having a potential role as important molecular adaptor
	CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	partner for RIMS1, RIMS2, RIMS3, RIMS4 that may bind to RIMs at the synapse in addition to Rab3
	RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca(2+) channel alpha-1 isoforms
	MYRIP accumulates granules in the cortical F-actin network not by direct interaction with MYO5A, but by indirect interaction with a specific form of MYO7A through its previously unknown binding partner, RIMBP2 (28673385)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS