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FLASH GENE
Symbol RIMBP2 contributors: npt/mct - updated : 15-02-2019
HGNC name RIMS binding protein 2
HGNC id 30339
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
 parathyroid    
Nervousbrain    
Respiratorylung    
Visualeye    
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor
Visualganglion cell
Visualrod photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three fibronectin type III-domains
  • three Src homology 3 domains, of which the second Src homology 3 domain binds to RIMS, domain probably recognizing specific PXXP motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • RIMBP family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text
  • synaptic junction
  • occuring postsynaptically in dendrites and cell bodies
  • basic FUNCTION
  • playing a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B
  • having a potential role as important molecular adaptor
  • CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • partner for RIMS1, RIMS2, RIMS3, RIMS4 that may bind to RIMs at the synapse in addition to Rab3
  • RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca(2+) channel alpha-1 isoforms
  • MYRIP accumulates granules in the cortical F-actin network not by direct interaction with MYO5A, but by indirect interaction with a specific form of MYO7A through its previously unknown binding partner, RIMBP2 (28673385)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS