Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RIMBP2 contributors: npt/mct - updated : 15-02-2019
HGNC name RIMS binding protein 2
HGNC id 30339
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three fibronectin type III-domains
  • three Src homology 3 domains, of which the second Src homology 3 domain binds to RIMS, domain probably recognizing specific PXXP motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • RIMBP family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text
  • synaptic junction
  • occuring postsynaptically in dendrites and cell bodies
  • basic FUNCTION
  • playing a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B
  • having a potential role as important molecular adaptor
  • CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • partner for RIMS1, RIMS2, RIMS3, RIMS4 that may bind to RIMs at the synapse in addition to Rab3
  • RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca(2+) channel alpha-1 isoforms
  • MYRIP accumulates granules in the cortical F-actin network not by direct interaction with MYO5A, but by indirect interaction with a specific form of MYO7A through its previously unknown binding partner, RIMBP2 (28673385)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS