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FLASH GENE
Symbol REN contributors: mct/npt - updated : 02-09-2008
HGNC name renin
HGNC id 9958
Corresponding disease
RTD4 renal tubular dysgenesis 4
UAKD2 uromodulin-associated kidney disease 2
Location 1q32.1      Physical location : 204.123.943 - 204.135.465
Synonym name
  • angiotensinogenase
  • angiotensin-forming enzyme
  • renin precursor, renal
  • Synonym symbol(s) FLJ10761
    EC.number 3.4.23.15
    DNA
    TYPE functioning gene
    STRUCTURE 11.52 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure enhancer 11 kb upstream of its gene that is critical for renin gene expression and physiological sequelae, including response to alteration in salt intake
    MAPPING cloned Y linked Y status confirmed
    Map cen - D1S53 - D1S52 ,REN - D1S54 - D1S70 - qter
    Physical map
    C1orf37 1q31.1 chromosome 1 open reading frame 37 PPFIA4 1q32.1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 MYOG 1q31-q41 myogenin (myogenic factor 4) ADORA1 1q32.1 adenosine A1 receptor MYBPH 1q32.1 myosin binding protein H CHI3L1 1q31-q32 chitinase 3-like 1 (cartilage glycoprotein-39) CHIT1 1q31-q32 chitinase 1 (chitotriosidase) LOC388729 1 LOC388729 BTG2 1q32 BTG family, member 2 FMOD 1q32.1 fibromodulin ATP2B4 1q32 ATPase, Ca++ transporting, plasma membrane 4 MGC5457 1q32.1 hypothetical protein MGC5457 LAX 1q32.1 hypothetical protein FLJ20340 KIAA0663 1q32.1 hypothetical protein FLJ20340 SNRPE 1q32 small nuclear ribonucleoprotein polypeptide E LOC391155 1 similar to KRT8 protein FLJ40343 1q32.1 hypothetical protein FLJ40343 SOX13 1q31.3-q32.1 SRY (sex determining region Y)-box 13 FLJ10761 1q32.1 putative ethanolamine kinase REN 1q32 renin KISS1 1q32 KiSS-1 metastasis-suppressor FLJ42654 1q32.1 FLJ42654 protein PEPP3 1q32.1 phosphoinositol 3-phosphate-binding protein-3 PPP1R15B 1q32.1 protein phosphatase 1, regulatory (inhibitor) subunit 15B PIK3C2B 1q32 phosphoinositide-3-kinase, class 2, beta polypeptide MDM4 1q32 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) GAC1 NFASC 1q32.1 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) CNTN2 1q32.1 contactin 2 (axonal) LOC388730 1 similar to RIKEN cDNA 4930429O20 RBBP5 1q32 retinoblastoma binding protein 5 KIAA0472
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1461 - 406 - Feldt (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Urinarybladder    
     kidneynephronrenal capsuleglomerulus 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarymesenchymal cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase A1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text secreted
    basic FUNCTION
  • aspartic endopeptidase, angiotensin-forming enzyme, converting angiotensinogen to angiotensin I
  • catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure
  • primary function of renin is the hydrolytic cleavage of angiotensinogen to angiotensin, with the subsequent stimulation of aldosterone production (Zivna 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PCBP1, ELAVL1, and HADHB
  • cell & other
    REGULATION
    induced by low blood pressure and hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s) RTD4 , UAKD2
    Susceptibility to arterial hypertension
    Variant & Polymorphism other polymorphisms in the kidney enhancer associated with arterial hypertension
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS