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FLASH GENE
Symbol RARRES3 contributors: mct - updated : 18-05-2010
HGNC name retinoic acid receptor responder (tazarotene induced) 3
HGNC id 9869
Location 11q12.3      Physical location : 63.304.272 - 63.313.929
Synonym name
  • retinoic acid inducible 1
  • tazarotene-induced gene 3
  • RAR-responsive protein TIG3
  • Synonym symbol(s) TIG3, RIG1, HRASLS4, MGC8906, RIG-1, PLA1/2-3
    DNA
    TYPE functioning gene
    STRUCTURE 9.66 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    POLR2G 11q13.1 polymerase (RNA) II (DNA directed) polypeptide G TAF6L 11q13.1 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC387617 11 hypothetical gene supported by NM_018336 LOC374395 11q12.3 similar to RIKEN cDNA 1810059G22 NXF1 11q12-q13 nuclear RNA export factor 1 STX5A 11cen-q12.1 syntaxin 5A FLJ10439 11q12.3 hypothetical protein FLJ10439 SLC3A2 11q12-q22 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 CHRM1 11q12-q13 cholinergic receptor, muscarinic 1 SLC22A6 11q13.1-q13.2 solute carrier family 22 (organic anion transporter), member 6 SLC22A8 11q11.7 solute carrier family 22 (organic anion transporter), member 8 LOC390207 11 similar to Tubulin alpha-4 chain (Alpha-tubulin 4) LOC390208 11 similar to ribosomal protein L29 MGC34821 11q12.3 hypothetical protein MGC34821 LOC387601  putative UST1-like organic anion transporter CCND2P 11q13 cyclin D2 pseudogene LOC387775 11 similar to organic anion transporter 6 SLC22A9 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 9 HRLP5 11q13.2 H-rev107-like protein 5 LGALS12 11q13 lectin, galactoside-binding, soluble, 12 (galectin 12) TMSL5 11 thymosin-like 5 RARRES3 11q23 retinoic acid receptor responder (tazarotene induced) 3 HRASLS2 11q13.1 HRAS-like suppressor 2 HRASLS3 11q13.1 HRAS-like suppressor 3 LOC283241 11q13.1 hypothetical protein LOC283241 DKFZP564J0863 11q13.1 DKFZP564J0863 protein RTN3 11q13 reticulon 3 LOC144097 11q13.1 hypothetical protein BC007540 MARK2 11q12-q13 MAP/microtubule affinity-regulating kinase 2 LOC283248 11q13.1 hypothetical protein LOC283248 FLJ13848 11q13.1 hypothetical protein FLJ13848 COX8 11q13.1 cytochrome c oxidase subunit VIII OTUB1 11q13.1 OTU domain, ubiquitin aldehyde binding 1 LRP16 11q11 LRP16 protein LOC387776 11 LOC387776 FLRT1 11q12-q13 fibronectin leucine rich transmembrane protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 779 18 164 - 2009 19615464
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Respiratorylung    
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region containing the CARD domain, conjugated to ubiquitin, and is required for RARRES3-dependent keratinocyte differentiation
  • minimal incorporation of ubiquitin to the C-terminal half, hydrophobic domain, two caspase activation and recruitment domains (CARDs)
  • three myristoylation sites
  • C-terminal helicase domain, membrane-anchoring domain
  • HOMOLOGY
    intraspecies homolog to REV107-1 tumor supressor
    Homologene
    FAMILY
  • lecithin retinol acyltransferase (LRAT) protein family
  • H-rev107 family
  • CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may function as an antiproliferative and antitumor agent
  • playing a pivotal role in the regulation of cytokine production induced by pathogens
  • implicated in innate immunity by sensing intracellular viral RNAs and inducing type I IFN production
  • critical regulatory role in modulating the generation and differentiation of granulocytes
  • initiates a signaling cascade that activates innate immune response by interferon and cytokine production, providing essential antiviral protection for the host
  • cytosolic receptor that recognizes viral RNA and activates the interferon-mediated innate antiviral response
  • playing a critical regulatory role in modulating the generation and differentiation of granulocytes (negatively regulating granulocytic proliferation)
  • with HRASLS2 and PLA2G16, are involved in the phospholipid metabolism with different physiological roles
  • important viral RNA recognition molecule, associated with the actin cytoskeleton and localized predominantly to actin-enriched membrane ruffles in non-polarized epithelial cells
  • physiological role in the regulation of cellular migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CYLD (negative regulator of RARRES3-mediated innate antiviral response)
  • caspase-1 physically interacted with full length RARRES3 (enzymatic activity of caspase-1 was necessary to control RARRES3, although it was not a substrate of proteolytic cleavage by caspase-1)
  • interaction with TGM1 does not require the N-terminal conserved domain
  • cell & other
    REGULATION
    activated by retinoic acid through the heterodimer of retinoic acid receptor and retinoic X receptor
    induced by by retinoic acid in head and neck and lung carcinoma cells
    tazarotene
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    leads to the development of a progressive myeloproliferative disorder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS