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FLASH GENE

Symbol

RARRES3

contributors: mct - updated : 18-05-2010

HGNC name	retinoic acid receptor responder (tazarotene induced) 3
HGNC id	9869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q12.3      Physical location : 63.304.272 - 63.313.929
Synonym name	retinoic acid inducible 1
	tazarotene-induced gene 3
	RAR-responsive protein TIG3
Synonym symbol(s)	TIG3, RIG1, HRASLS4, MGC8906, RIG-1, PLA1/2-3

DNA

TYPE	functioning gene
STRUCTURE	9.66 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004585 4 - 779 NP_004576 18 164 - 2009 19615464

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Respiratory lung         Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal region containing the CARD domain, conjugated to ubiquitin, and is required for RARRES3-dependent keratinocyte differentiation
	minimal incorporation of ubiquitin to the C-terminal half, hydrophobic domain, two caspase activation and recruitment domains (CARDs)
	three myristoylation sites
	C-terminal helicase domain, membrane-anchoring domain

HOMOLOGY

intraspecies

homolog to REV107-1 tumor supressor

Homologene

FAMILY	lecithin retinol acyltransferase (LRAT) protein family
	H-rev107 family

CATEGORY

receptor nuclear

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	may function as an antiproliferative and antitumor agent
	playing a pivotal role in the regulation of cytokine production induced by pathogens
	implicated in innate immunity by sensing intracellular viral RNAs and inducing type I IFN production
	critical regulatory role in modulating the generation and differentiation of granulocytes
	initiates a signaling cascade that activates innate immune response by interferon and cytokine production, providing essential antiviral protection for the host
	cytosolic receptor that recognizes viral RNA and activates the interferon-mediated innate antiviral response
	playing a critical regulatory role in modulating the generation and differentiation of granulocytes (negatively regulating granulocytic proliferation)
	with HRASLS2 and PLA2G16, are involved in the phospholipid metabolism with different physiological roles
	important viral RNA recognition molecule, associated with the actin cytoskeleton and localized predominantly to actin-enriched membrane ruffles in non-polarized epithelial cells
	physiological role in the regulation of cellular migration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with CYLD (negative regulator of RARRES3-mediated innate antiviral response)
	caspase-1 physically interacted with full length RARRES3 (enzymatic activity of caspase-1 was necessary to control RARRES3, although it was not a substrate of proteolytic cleavage by caspase-1)
	interaction with TGM1 does not require the N-terminal conserved domain

cell & other

REGULATION

activated by

retinoic acid through the heterodimer of retinoic acid receptor and retinoic X receptor

induced by	by retinoic acid in head and neck and lung carcinoma cells
		tazarotene

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   leads to the development of a progressive myeloproliferative disorder

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS