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FLASH GENE
Symbol RARRES3 contributors: mct - updated : 18-05-2010
HGNC name retinoic acid receptor responder (tazarotene induced) 3
HGNC id 9869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region containing the CARD domain, conjugated to ubiquitin, and is required for RARRES3-dependent keratinocyte differentiation
  • minimal incorporation of ubiquitin to the C-terminal half, hydrophobic domain, two caspase activation and recruitment domains (CARDs)
  • three myristoylation sites
  • C-terminal helicase domain, membrane-anchoring domain
    • HOMOLOGY
    intraspecies homolog to REV107-1 tumor supressor
    Homologene
    FAMILY
  • lecithin retinol acyltransferase (LRAT) protein family
  • H-rev107 family
    • CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may function as an antiproliferative and antitumor agent
  • playing a pivotal role in the regulation of cytokine production induced by pathogens
  • implicated in innate immunity by sensing intracellular viral RNAs and inducing type I IFN production
  • critical regulatory role in modulating the generation and differentiation of granulocytes
  • initiates a signaling cascade that activates innate immune response by interferon and cytokine production, providing essential antiviral protection for the host
  • cytosolic receptor that recognizes viral RNA and activates the interferon-mediated innate antiviral response
  • playing a critical regulatory role in modulating the generation and differentiation of granulocytes (negatively regulating granulocytic proliferation)
  • with HRASLS2 and PLA2G16, are involved in the phospholipid metabolism with different physiological roles
  • important viral RNA recognition molecule, associated with the actin cytoskeleton and localized predominantly to actin-enriched membrane ruffles in non-polarized epithelial cells
  • physiological role in the regulation of cellular migration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CYLD (negative regulator of RARRES3-mediated innate antiviral response)
  • caspase-1 physically interacted with full length RARRES3 (enzymatic activity of caspase-1 was necessary to control RARRES3, although it was not a substrate of proteolytic cleavage by caspase-1)
  • interaction with TGM1 does not require the N-terminal conserved domain
    • cell & other
    REGULATION
    activated by retinoic acid through the heterodimer of retinoic acid receptor and retinoic X receptor
    induced by by retinoic acid in head and neck and lung carcinoma cells
    tazarotene
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    leads to the development of a progressive myeloproliferative disorder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS