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FLASH GENE
Symbol PSMA3 contributors: mct - updated : 24-04-2012
HGNC name proteasome (prosome, macropain) subunit, alpha type, 3
HGNC id 9532
Location 14q23.1      Physical location : 58.711.592 - 58.738.726
Synonym name
  • macropain subunit C8
  • multicatalytic endopeptidase complex subunit C8
  • Synonym symbol(s) PSC3, HC8, PSA3, MGC12306, MGC3263
    EC.number 3.4.25.1
    DNA
    TYPE functioning gene
    STRUCTURE 27.20 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Physical map
    SEC10L1 14q22.2 SEC10-like 1 (S. cerevisiae) C14orf108 14q22.2 chromosome 14 open reading frame 108 C14orf35 14q22.2 chromosome 14 open reading frame 35 C14orf105 14q22.2 chromosome 14 open reading frame 105 LOC341880 LOC256755 14q22.3 similar to TLS-associated protein TASR-2 LOC390481 14 LOC390481 UBA52P3 14 ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3 ACTR10 14q22.2 actin-related protein 10 homolog (S. cerevisiae) PSMA3 14q23 proteasome (prosome, macropain) subunit, alpha type, 3 HMGB1P 14 high-mobility group box 1 pseudogene RBBP1 14q22.3 retinoblastoma binding protein 1 LOC387990 14 similar to TIMM9 TIMM9 14q22.3-q24 translocase of inner mitochondrial membrane 9 homolog (yeast) KIAA0586 14q23.1 KIAA0586 HSBP1P1 14 heat shock factor binding protein 1 pseudogene 1 HNRPCP 14 heterogeneous nuclear ribonucleoprotein C pseudogene DACT1 14q22.3 dapper homolog 1, antagonist of beta-catenin (xenopus) LOC387991 14 similar to ribosomal protein L31 LOC390482 14 similar to Aldo-keto reductase family 1, member B1 PPIAP5 14 peptidylprolyl isomerase A (cyclophilin A) pseudogene 5 DAAM1 14q22.3 dishevelled associated activator of morphogenesis 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 993 - 248 - 995 7857283
    11 - 1014 - 255 - 995 7857283
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Hearing/Equilibriumear   highly
    Respiratorylung    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY to peptidase family T1A
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • exhibits endoribonuclease activity controlled by extra-cellular stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the AURKB (Aurora-B might undergo degradation by binding to PSMA3 in a proteasome-dependent manner during mitosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS