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FLASH GENE
Symbol PSMA3 contributors: mct - updated : 24-04-2012
HGNC name proteasome (prosome, macropain) subunit, alpha type, 3
HGNC id 9532
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY to peptidase family T1A
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • exhibits endoribonuclease activity controlled by extra-cellular stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the AURKB (Aurora-B might undergo degradation by binding to PSMA3 in a proteasome-dependent manner during mitosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS