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FLASH GENE
Symbol PSMA3 contributors: mct - updated : 24-04-2012
HGNC name proteasome (prosome, macropain) subunit, alpha type, 3
HGNC id 9532
DNA
TYPE functioning gene
STRUCTURE 27.20 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
Physical map
SEC10L1 14q22.2 SEC10-like 1 (S. cerevisiae) C14orf108 14q22.2 chromosome 14 open reading frame 108 C14orf35 14q22.2 chromosome 14 open reading frame 35 C14orf105 14q22.2 chromosome 14 open reading frame 105 LOC341880 LOC256755 14q22.3 similar to TLS-associated protein TASR-2 LOC390481 14 LOC390481 UBA52P3 14 ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3 ACTR10 14q22.2 actin-related protein 10 homolog (S. cerevisiae) PSMA3 14q23 proteasome (prosome, macropain) subunit, alpha type, 3 HMGB1P 14 high-mobility group box 1 pseudogene RBBP1 14q22.3 retinoblastoma binding protein 1 LOC387990 14 similar to TIMM9 TIMM9 14q22.3-q24 translocase of inner mitochondrial membrane 9 homolog (yeast) KIAA0586 14q23.1 KIAA0586 HSBP1P1 14 heat shock factor binding protein 1 pseudogene 1 HNRPCP 14 heterogeneous nuclear ribonucleoprotein C pseudogene DACT1 14q22.3 dapper homolog 1, antagonist of beta-catenin (xenopus) LOC387991 14 similar to ribosomal protein L31 LOC390482 14 similar to Aldo-keto reductase family 1, member B1 PPIAP5 14 peptidylprolyl isomerase A (cyclophilin A) pseudogene 5 DAAM1 14q22.3 dishevelled associated activator of morphogenesis 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 993 - 248 - 995 7857283
11 - 1014 - 255 - 995 7857283
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Hearing/Equilibriumear   highly
Respiratorylung    
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY to peptidase family T1A
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • exhibits endoribonuclease activity controlled by extra-cellular stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the AURKB (Aurora-B might undergo degradation by binding to PSMA3 in a proteasome-dependent manner during mitosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS