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FLASH GENE
Symbol PROS1 contributors: mct - updated : 22-12-2009
HGNC name protein S (alpha)
HGNC id 9456
Corresponding disease
PROS1 pro-S deficiency
Location 3q11.2      Physical location : 93.591.881 - 93.692.934
Synonym name
  • vitamin K-dependent plasma protein S
  • protein Sa
  • Synonym symbol(s) PROS, PS21, PS22, PS23, PS24, PS25, PSA
    DNA
    TYPE functioning gene
    STRUCTURE 101.05 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   hormone   HRE
    text structure
  • the liver-specific factors hepatocyte nuclear factor 1 (HNF1) and HNF4 bind regions of the protein S promoter, which lie within the identified protein binding sites V and VIII, respectively, and HNF4 activates the promoter
  • PROS1 promoter is responsive to progesterone and other progestins via a mechanism involving PR-B (progesterone receptor isoform B) interacting with a PRE (progesterone response element) (Hughes 2007)
  • MAPPING cloned Y linked N status confirmed
    Physical map
    PROS1 3p11 protein S (alpha) DKFZp761H079 3q11.2 hypothetical protein DKFZp761H079 LOC200895 3q11.2 hypothetical protein LOC200895 FLJ22609 3q11.2 hypothetical protein FLJ22609 LOC389137 3 similar to SVH-B LOC344620 3q11.2 similar to CG17293-PA LOC255025 3q11.2 hypothetical protein LOC255025 LOC285217 3q12.1 similar to heterogeneous nuclear ribonucleoprotein K isoform a; dC-stretch binding protein; transformation upregulated nuclear protein LOC391556 3 similar to Chromatin assembly factor 1 subunit C (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-Ip48) (Retinoblastoma binding protein p48) (Retinoblastoma-binding protein 4) (RBBP-4) (MSI1 pr LOC391557 3 similar to KIAA1470 protein LOC200842 3q12.1 similar to hypothetical protein H41 LOC203806 3q12.1 hypothetical protein LOC203806 DKFZp434C1418 3q12.1 hypothetical protein DKFZp434C1418 ARL6 3q12.1 ADP-ribosylation factor-like 6 MINA53 3q12.1-q12.2 myc-induced nuclear antigen, 53 kDa LOC200959 3q12.2 similar to Gamma-aminobutyric-acid receptor rho-3 subunit precursor (GABA(A) receptor) LOC389138 3 similar to olfactory receptor GA_x54KRFPKG5P-55348161-55347241 OR5K1 3p26.1 olfactory receptor, family 5, subfamily K, member 1 LOC391558 3 similar to Olfactory receptor 5K2 C3orf4 3p11-q11 chromosome 3 open reading frame 4 GPR15 3q11.2-q13.1 G protein-coupled receptor 15 CPO 3q12 coproporphyrinogen oxidase (coproporphyria, harderoporphyria) LOC339843 3q12.2 similar to Nedd-4-like ubiquitin-protein ligase WWP1 (WW domain-containing protein 1) SIAT10 3q12.2 sialyltransferase 10 (alpha-2,3-sialyltransferase VI) ESDN 3q12.2 sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3595 - 676 - 2008 18680534
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   highly
    Reproductivefemale systemplacenta  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one gamma carboxyglutamic domain
  • two laminin A/neurexin/sex hormone-binding globulin repeats (LNS)
  • four EGF-like domains (GLA domain)
  • conjugated GlycoP
    mono polymer homomer , monomer , polymer
    HOMOLOGY
    Homologene
    FAMILY
  • AXL family of receptor tyrosine kinases
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secreted from platelets alpha granules
    basic FUNCTION
  • co-factor for activated protein C to inactivate coagulation factors
  • playing a pivotal role in inflammation
  • with TFPI, are major regulators of thrombin generation both in the absence and presence of activated protein C (APC)
  • with TFPI, act together in down-regulating coagulation )
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn(2+) is required for PROS1-direct and efficient FXa binding and may play a role in stabilizing PROS1 conformation
  • protein
  • binding factors Xa,Va to inhibit prothrombinase
  • interfering with plasminogen binding on cell surface
  • cofactor for activated protein C (APC), which inactivates coagulation factors (F) Va and VIIIa
  • dependence on vitamin K-dependent PROS1 for eukaryotic cell secretion of C4BPB
  • cell & other
    REGULATION
    inhibited by binding to C4BP
    Other vitamin K-dependent
    ASSOCIATED DISORDERS
    corresponding disease(s) PROS1
    related resource Protein S Deficiency: A database of Mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS