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FLASH GENE
Symbol PROS1 contributors: mct - updated : 22-12-2009
HGNC name protein S (alpha)
HGNC id 9456
DNA
TYPE functioning gene
STRUCTURE 101.05 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   hormone   HRE
text structure
  • the liver-specific factors hepatocyte nuclear factor 1 (HNF1) and HNF4 bind regions of the protein S promoter, which lie within the identified protein binding sites V and VIII, respectively, and HNF4 activates the promoter
  • PROS1 promoter is responsive to progesterone and other progestins via a mechanism involving PR-B (progesterone receptor isoform B) interacting with a PRE (progesterone response element) (Hughes 2007)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3595 - 676 - 2008 18680534
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   highly
    Reproductivefemale systemplacenta  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one gamma carboxyglutamic domain
  • two laminin A/neurexin/sex hormone-binding globulin repeats (LNS)
  • four EGF-like domains (GLA domain)
  • conjugated GlycoP
    mono polymer homomer , monomer , polymer
    HOMOLOGY
    Homologene
    FAMILY
  • AXL family of receptor tyrosine kinases
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secreted from platelets alpha granules
    basic FUNCTION
  • co-factor for activated protein C to inactivate coagulation factors
  • playing a pivotal role in inflammation
  • with TFPI, are major regulators of thrombin generation both in the absence and presence of activated protein C (APC)
  • with TFPI, act together in down-regulating coagulation )
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn(2+) is required for PROS1-direct and efficient FXa binding and may play a role in stabilizing PROS1 conformation
  • protein
  • binding factors Xa,Va to inhibit prothrombinase
  • interfering with plasminogen binding on cell surface
  • cofactor for activated protein C (APC), which inactivates coagulation factors (F) Va and VIIIa
  • dependence on vitamin K-dependent PROS1 for eukaryotic cell secretion of C4BPB
  • cell & other
    REGULATION
    inhibited by binding to C4BP
    Other vitamin K-dependent
    ASSOCIATED DISORDERS
    corresponding disease(s) PROS1
    related resource Protein S Deficiency: A database of Mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS