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FLASH GENE
Symbol PROS1 contributors: mct - updated : 22-12-2009
HGNC name protein S (alpha)
HGNC id 9456
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3595 - 676 - 2008 18680534
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousbrain   highly
Reproductivefemale systemplacenta  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticplasma   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one gamma carboxyglutamic domain
  • two laminin A/neurexin/sex hormone-binding globulin repeats (LNS)
  • four EGF-like domains (GLA domain)
  • conjugated GlycoP
    mono polymer homomer , monomer , polymer
    HOMOLOGY
    Homologene
    FAMILY
  • AXL family of receptor tyrosine kinases
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secreted from platelets alpha granules
    basic FUNCTION
  • co-factor for activated protein C to inactivate coagulation factors
  • playing a pivotal role in inflammation
  • with TFPI, are major regulators of thrombin generation both in the absence and presence of activated protein C (APC)
  • with TFPI, act together in down-regulating coagulation )
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn(2+) is required for PROS1-direct and efficient FXa binding and may play a role in stabilizing PROS1 conformation
  • protein
  • binding factors Xa,Va to inhibit prothrombinase
  • interfering with plasminogen binding on cell surface
  • cofactor for activated protein C (APC), which inactivates coagulation factors (F) Va and VIIIa
  • dependence on vitamin K-dependent PROS1 for eukaryotic cell secretion of C4BPB
  • cell & other
    REGULATION
    inhibited by binding to C4BP
    Other vitamin K-dependent
    ASSOCIATED DISORDERS
    corresponding disease(s) PROS1
    related resource Protein S Deficiency: A database of Mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS