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FLASH GENE
Symbol PRKAG2 contributors: mct/npt - updated : 30-11-2009
HGNC name protein kinase, AMP-activated, gamma 2 non-catalytic subunit
HGNC id 9386
Corresponding disease
GSDH glycogen storage disease of the heart
WPW Wolff-Parkinson-White syndrome
Location 7q36.1      Physical location : 151.253.202 - 151.574.316
Synonym name
  • AMP-activated protein kinase gamma2 subunit
  • AMPK gamma2
    • Synonym symbol(s) AMPKG2, CMH6, AAKG, AAKH, AAKG2, H91620p
    DNA
    TYPE functioning gene
    STRUCTURE 321.12 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure (PRKAG2b)
    MAPPING cloned Y linked N status confirmed
    Map cen - D7S2426 - D7S605 - D7S636 - D7S642 - D7S2641 - D7S2439 - PRKAG2 - RHEB - D7S2462 - D7S483 - D7S798 - qter
    Authors Lang (00) Gollog (01)
    Physical map
    FLJ39415 7q36.1 hypothetical protein FLJ39415 ABCB8 7q35-q36 ATP-binding cassette, sub-family B (MDR/TAP), member 8 ACCN3 7q35 amiloride-sensitive cation channel 3, testis CDK5 7q36 cyclin-dependent kinase 5 SLC4A2 7q35-q36 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) FASTK 7q35 FAST kinase C7orf21 7q36.1 chromosome 7 open reading frame 21 CENTG3 7q36.1£7q36.1 centaurin, gamma 3 LOC392152 7 similar to gastrulation brain homeobox 1 ASB10 7q35 ankyrin repeat and SOCS box-containing 10 LOC155046 7q36.1 similar to hypothetical protein 4931409K22 LOC346545 7q36.1 similar to hypothetical protein FLJ22527 ABCF2 7q35-q36 ATP-binding cassette, sub-family F (GCN20), member 2 CSGlcA-T 7q36.1 KIAA1402 protein SMARCD3 7q35-q36 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 NYREN18 7q36 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 LOC349136 7q36.1 hypothetical protein LOC349136 CRYGN 7q36.1 crystallin, gamma N RHEB 7q36 Ras homolog enriched in brain ETF1P2 7q11 eukaryotic translation termination factor 1 pseudogene 2 PRKAG2 7q36 protein kinase, AMP-activated, gamma 2 non-catalytic subunit GALNT15 7q36.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
    RNA
    TRANSCRIPTS type messenger
    text may be other transcripts (Lang) 63rd
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 3154 58 525 - Morita (2008)
  • containing an alternate 5' exon compared to variant 1
  • start of translation from a downstream AUG codon compared to variant 1
    • 16 splicing 2248 37.4 328 heart, testis, placenta Cheung, Lang, Morita (2008
  • also called PRKAG2B
  • containing a distinct 5' UTR compared to variant 1
  • lacking a large in-frame portion of the 5' coding region compared to variant 1
    • 16 splicing 3423 62.9 569 highly in heart, lower in skeletal muscle, kidney, spleen, testis Lang, Cheung, Morita (2008)
    also called PRKAG2A
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine  moderately
     intestinelarge intestinecolon moderately
    Endocrineadrenal gland   moderately
     parathyroid   moderately
    Lymphoid/Immunethymus   moderately
    Reproductivefemale systemplacenta  predominantly
     female systemovary  highly
     male systemtestis   
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four cystathionine-beta-synthase (CBS) forming a stable globular domain
    • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to rattus Prkag2 (98.5pc)
    ortholog to murine Prkag2 (93.8pc)
    intraspecies homolog to PRKAG1
    Homologene
    FAMILY
  • 5'-AMP-activated protein kinase gamma subunit family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • being responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase
  • regulating cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase
  • involved in the pathogenesis of Alzheimer disease
  • stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy consuming functions, such as protein and cholesterol synthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid biosynthesis ; cholesterol biosynthesis
    a component
  • heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cAMP
    ASSOCIATED DISORDERS
    corresponding disease(s) WPW , GSDH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS