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GENATLAS PHENOTYPE
last update : 27-11-2009
Symbol WPW
Location 7q36.1
Name Wolff-Parkinson-White syndrome
Corresponding gene PRKAG2
Main clinical features
  • characterized by paroxysmal supraventriculer tachycardia
  • associated with ventricular preexcitation, conducting abnormalities and cardiac hypertrophy, producing symptoms of presyncope, syncope, shortness of breath and eventually sudden death, treatable by ablation of accessory atrioventricular pathways
    • Genetic determination autosomal dominant
    Function/system disorder cardiovascular
    Type disease
    Gene product
    Name protein kinase, AMP activation, gamma 2
    Mechanism(s)
    Gene mutationChromosome rearrangementEffectComments
    various types     mutation R302Q in two families
    Remark(s)