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FLASH GENE
Symbol PRDX5 contributors: mct/npt - updated : 21-10-2009
HGNC name peroxiredoxin 5
HGNC id 9355
Location 11q13.1      Physical location : 64.085.568 - 64.089.282
Synonym name
  • mammalian antioxidant enzyme B166
  • antioxidant enzyme B166
  • thioredoxin peroxidase PMP20
  • Alu corepressor 1
  • liver tissue 2D-page spot 71B
  • Synonym symbol(s) ACR1, B166, PRXV, PMP20, AOEB166, MGC117264, PLP, PRDX6, SBBI10, MGC142285, SBBI10, MGC142283
    EC.number 1.11.1.15
    DNA
    TYPE functioning gene
    STRUCTURE 3.71 kb     6 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure contain clusters of antioxidant response elements, which can bind the transcription factor NRF2 (Kropotov 2006)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC283248 11q13.1 hypothetical protein LOC283248 FLJ13848 11q13.1 hypothetical protein FLJ13848 COX8 11q13.1 cytochrome c oxidase subunit VIII OTUB1 11q13.1 OTU domain, ubiquitin aldehyde binding 1 LRP16 11q11 LRP16 protein LOC387776 11 LOC387776 FLRT1 11q12-q13 fibronectin leucine rich transmembrane protein 1 STIP1 11q13.2 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) URP2 11q13.1 UNC-112 related protein 2 short form MGC11134 11q13.1 tRNA splicing 2' phosphotransferase 1 MGC13045 11q13.1 hypothetical protein MGC13045 DNAJC4 11q13 DnaJ (Hsp40) homolog, subfamily C, member 4 VEGFB 11q13 vascular endothelial growth factor B FKBP2 11q13.1 FK506 binding protein 2, 13kDa PPP1R14B 11q13 protein phosphatase 1, regulatory (inhibitor) subunit 14B PLCB3 11q13.1-q13.2 phospholipase C, beta 3 (phosphatidylinositol-specific) BAD 11q12.3 BCL2-antagonist of cell death C11ORF4 11cen-q22.3 chromosome 11 hypothetical protein ORF4 KCNK4 11q13 potassium channel, subfamily K, member 4 ESRRA 11q12-q13 estrogen-related receptor alpha HSPC152 11q13.1 hypothetical protein HSPC152 PRDX5 11q13.1 peroxiredoxin 5 FLJ37970 11q12.3 hypothetical protein FLJ37970 RPS6KA4 11q11-q13 ribosomal protein S6 kinase, 90kDa, polypeptide 4 LOC387777 11 LOC387777 FLJ37045 11q13.1 hypothetical protein FLJ37045 SLC22A11 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 11 SLC22A12 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 12 NRXN2 11q13.2 neurexin 2
    RNA
    TRANSCRIPTS type messenger
    text producing three isoforms by use of alternative initiation codons in the same reading frame (one mitochondrial and the second cytoplasmic/peroxisomal)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 initiation site 959 22 214 mitochondrial Banmeyer, Smeets (2008)
    also called PRDX5-m
    5 initiation site 827 - 170 cytoplasmic/peroxisomal Ren, Banmeyer, Smeets (2008)
    also called PRDX5-p or variant 2
    4 - 692 - 125 - Banmeyer, Smeets (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • features of mitochondrial and peroxismal targeting sequences
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Prdx6
    homolog to murine CG7217
    homolog to C.elegans F45F2.9
    Homologene
    FAMILY
  • peroxiredoxin 2 family
  • AhpC/TSA peroxiredoxin antioxidants subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • peroxynitrite reductase, playing an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes
  • reducing hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system
  • protecting mitochondrial DNA (mtDNA) from oxidative attacks
  • may play an important role in mitochondrial genome stability
  • thiol-specific antioxidant protein that is highly expressed in cancer cells (Shiota 2008)
  • might protect cells from oxidative stress (Shiota 2008)
  • transcriptional corepressor, as a peroxisomal/mitochondrial antioxidant protein, and as an inhibitor of TP53-dependent apoptosis (Kropotov 2006)
  • constitutively expressed PRDX5 gene plays an important role in protecting the genome against oxidation and may also be involved in the control of transcription of noncoding DNA (Kropotov 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation , respiration , electron transport , detoxification
    text
  • respiratory gaseous exchange
  • inflammatory response
  • PATHWAY
    metabolism
    signaling
    involved in intracellular redox signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS