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FLASH GENE

Symbol

PRDX5

contributors: mct/npt - updated : 21-10-2009

HGNC name	peroxiredoxin 5
HGNC id	9355

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	producing three isoforms by use of alternative initiation codons in the same reading frame (one mitochondrial and the second cytoplasmic/peroxisomal)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012094 6 initiation site 959 NP_036226 22 214 mitochondrial Banmeyer, Smeets (2008) also called PRDX5-m NM_181651 5 initiation site 827 NP_857634 - 170 cytoplasmic/peroxisomal Ren, Banmeyer, Smeets (2008) also called PRDX5-p or variant 2 NM_181652 4 - 692 NP_857635 - 125 - Banmeyer, Smeets (2008)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver       highly Endocrine pancreas       highly Nervous brain       highly Reproductive male system prostate     highly Respiratory lung       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

features of mitochondrial and peroxismal targeting sequences

mono polymer

monomer

HOMOLOGY

interspecies	ortholog to murine Prdx6
	homolog to murine CG7217
	homolog to C.elegans F45F2.9

Homologene

FAMILY	peroxiredoxin 2 family
	AhpC/TSA peroxiredoxin antioxidants subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,peroxisome

basic FUNCTION	peroxynitrite reductase, playing an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes
	reducing hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system
	protecting mitochondrial DNA (mtDNA) from oxidative attacks
	may play an important role in mitochondrial genome stability
	thiol-specific antioxidant protein that is highly expressed in cancer cells (Shiota 2008)
	might protect cells from oxidative stress (Shiota 2008)
	transcriptional corepressor, as a peroxisomal/mitochondrial antioxidant protein, and as an inhibitor of TP53-dependent apoptosis (Kropotov 2006)
	constitutively expressed PRDX5 gene plays an important role in protecting the genome against oxidation and may also be involved in the control of transcription of noncoding DNA (Kropotov 2006)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation , respiration , electron transport , detoxification

text	respiratory gaseous exchange
	inflammatory response

PATHWAY

metabolism

signaling

involved in intracellular redox signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS