basic FUNCTION
| peroxynitrite reductase, playing an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes |
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reducing hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system |
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protecting mitochondrial DNA (mtDNA) from oxidative attacks |
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may play an important role in mitochondrial genome stability |
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thiol-specific antioxidant protein that is highly expressed in cancer cells (Shiota 2008) |
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might protect cells from oxidative stress (Shiota 2008) |
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transcriptional corepressor, as a peroxisomal/mitochondrial antioxidant protein, and as an inhibitor of TP53-dependent apoptosis (Kropotov 2006) |
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constitutively expressed PRDX5 gene plays an important role in protecting the genome against oxidation and may also be involved in the control of transcription of noncoding DNA (Kropotov 2006) |