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FLASH GENE
Symbol PRDX5 contributors: mct/npt - updated : 21-10-2009
HGNC name peroxiredoxin 5
HGNC id 9355
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • features of mitochondrial and peroxismal targeting sequences
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Prdx6
    homolog to murine CG7217
    homolog to C.elegans F45F2.9
    Homologene
    FAMILY
  • peroxiredoxin 2 family
  • AhpC/TSA peroxiredoxin antioxidants subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • peroxynitrite reductase, playing an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes
  • reducing hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system
  • protecting mitochondrial DNA (mtDNA) from oxidative attacks
  • may play an important role in mitochondrial genome stability
  • thiol-specific antioxidant protein that is highly expressed in cancer cells (Shiota 2008)
  • might protect cells from oxidative stress (Shiota 2008)
  • transcriptional corepressor, as a peroxisomal/mitochondrial antioxidant protein, and as an inhibitor of TP53-dependent apoptosis (Kropotov 2006)
  • constitutively expressed PRDX5 gene plays an important role in protecting the genome against oxidation and may also be involved in the control of transcription of noncoding DNA (Kropotov 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation , respiration , electron transport , detoxification
    text
  • respiratory gaseous exchange
  • inflammatory response
  • PATHWAY
    metabolism
    signaling
    involved in intracellular redox signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS