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FLASH GENE
Symbol PRCC contributors: mct - updated : 09-06-2020
HGNC name proline rich mitotic checkpoint control factor
HGNC id 9343
Location 1q23.1      Physical location : 156.737.273 - 156.770.604
Synonym name
  • proline-rich protein PRCC
  • papillary renal cell carcinoma (translocation-associated)
  • Synonym symbol(s) RCCP1, TPRC, MGC4723, MGC17178
    DNA
    TYPE breakpoint
    STRUCTURE 33.28 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    Map cen - TCHH - IVL - SPRR1A - LOR - S100A@ - (tX;1 ) - SPTA1 - CRP - APCS - FCER1A - ATP1A2 - APOA2 APOA2 - qter
    Authors Weterman (96)
    RNA
    TRANSCRIPTS type untranslated
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2068 - 491 - 2016 26871637
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     salivary gland   highly
    Reproductivefemale systemuteruscervix highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text ubiquitous
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    high proline content
    HOMOLOGY
    interspecies homolog to murine Prcc
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • may be involved in process of mitotic checkpoint control mechanism
  • involved in ribosome processing, protein synthesis, cell cycle and cell proliferation
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PEAR1 cell-specific methylation sensitive region in endothelial cells and megakaryocytes that showed strong chromosomal interactions with RRNAD1, HDGF and PRCC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    in papillary renal cell carcinoma with translocation t(X;1)(p11.2;q21.2), involving a 48bp segment fused with the 5'end of TFE3 (see symbol and RCCPX)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS