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FLASH GENE
Symbol PRCC contributors: mct - updated : 09-06-2020
HGNC name proline rich mitotic checkpoint control factor
HGNC id 9343
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
high proline content
HOMOLOGY
interspecies homolog to murine Prcc
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
basic FUNCTION
  • may be involved in process of mitotic checkpoint control mechanism
  • involved in ribosome processing, protein synthesis, cell cycle and cell proliferation
    • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PEAR1 cell-specific methylation sensitive region in endothelial cells and megakaryocytes that showed strong chromosomal interactions with RRNAD1, HDGF and PRCC
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    in papillary renal cell carcinoma with translocation t(X;1)(p11.2;q21.2), involving a 48bp segment fused with the 5'end of TFE3 (see symbol and RCCPX)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS