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FLASH GENE

Symbol

PRCC

contributors: mct - updated : 09-06-2020

HGNC name	proline rich mitotic checkpoint control factor
HGNC id	9343

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   salivary gland       highly Reproductive female system uterus cervix   highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	ubiquitous

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

high proline content

HOMOLOGY

interspecies

homolog to murine Prcc

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles

basic FUNCTION	may be involved in process of mitotic checkpoint control mechanism
	involved in ribosome processing, protein synthesis, cell cycle and cell proliferation

CELLULAR PROCESS	cell cycle, division, mitosis
	cell cycle, checkpoint

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

PEAR1 cell-specific methylation sensitive region in endothelial cells and megakaryocytes that showed strong chromosomal interactions with RRNAD1, HDGF and PRCC

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       in papillary renal cell carcinoma with translocation t(X;1)(p11.2;q21.2), involving a 48bp segment fused with the 5'end of TFE3 (see symbol and RCCPX)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS