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Symbol PPP2CA contributors: mct/npt/pgu - updated : 10-10-2017
HGNC name protein phosphatase 2, catalytic subunit, alpha isozyme
HGNC id 9299
Location 5q31.1      Physical location : 133.532.148 - 133.561.950
Synonym name
  • replication protein C
  • serine/threonine-protein phosphatase 2A catalytic subunit
  • alpha isoform
  • protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
  • replication protein C
  • Synonym symbol(s) PP2CA, PP2A-C, RP-C,PP2A-alpha, PP2A
    TYPE functioning gene
    STRUCTURE 29.80 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D5S1766 - D5S2543 - D5S1429 - D5S1947 - D5S458 - D5S808 - D5S396 - PPP2CA - HSPA4 - D5S1697 - D5S1375 - D5S1391 - D5S816 - IL9 - TGFB1 - SMAD5 - D5S393 - D5S89 - qter
    Physical map
    HSPA4 5q31.1-q32 heat shock 70kDa protein 4 KIAA1061 5q31.1 KIAA1061 protein HTGN29 5q31.1 HTGN29 protein VDAC1 5q31 voltage-dependent anion channel 1 TCF7 5q31.1 transcription factor 7 (T-cell specific, HMG-box) SKP1A 7q11.2 S-phase kinase-associated protein 1A (p19A) PPP2CA 5q23-q31 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform CDKL3 5q31 cyclin-dependent kinase-like 3 UBE2B 5q31 ubiquitin-conjugating enzyme E2B (RAD6 homolog) MGC13017 5q31.2 similar to RIKEN cDNA A430101B06 gene LOC391833 5 similar to 40S ribosomal protein S10 PHF15 5q31.2 PHD finger protein 15 SARA2 5q31.1 SAR1a gene homolog 2 (S. cerevisiae) SEC24A 5 SEC24 related gene family, member A (S. cerevisiae) CAMLG 5q23 calcium modulating ligand DDX46 5q31.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 FLJ37562 5q31.2 hypothetical protein FLJ37562 FLJ22625 5q31.2 hypothetical protein FLJ22625 DCOHM 5q31.2 hypothetical protein FLJ22625 CATSPER3 5q31.2 cation channel, sperm associated 3 PITX1 5q31 paired-like homeodomain transcription factor 1 LOC389328 5 LOC389328 LOC389329 5 LOC389329 H2AFY 5q31.3-q32 H2A histone family, member Y
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2643 35.5 309 - 1991 1846293
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    at STAGE
    physiological period embryo, pregnancy
  • C terminal carboxyl group methylated by carboxyl methyltransferase
  • PPP phosphatase family
  • PP-1 subfamily
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • protein phosphatase 2A, catalytic subunit playing a pivotal role in gastrulation and neurulation in mouse
  • antagonizing CDC2/CCNB1complex which regulates the G2-M transition in the cell cycle
  • function as tumor suppressor protein, and important physiological regulator of cell growth and of cellular stress signaling
  • appears to function as an endogenous regulator of SPHK1 phosphorylation
  • interacts with epithelial tight junctions and negatively regulates the integrity of the tight junction
  • in the absence of netrin-1, recruitment of PPP2CA to UNC5B allows the activation of DAPK1 via a PPP2CA-mediated dephosphorylation and this mechanism is involved in angiogenesis regulation
  • CELLULAR PROCESS cell cycle, checkpoint
    a component
  • complexing with a 65kDa regulatory subunit
  • catalytic subunit of the ubiquitous Ser/Thr protein phosphatase PP2A could interact with the C-ter of KISS1R
  • STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases
    small molecule
  • associating with IGBP1
  • with GRM3(by Cterminal cytoplasmic tail)
  • PPP2CA involvement is a molecular mechanism for FCAR ligand binding regulation, a key step in initiating an immune response
  • IGBP1 plays a required role in regulating the assembly and maintenance of adaptive PPP2CA phosphatase complexes
  • PPP2CA inhibiting IL23A production by suppressing the expression of the IL23A gene
  • in addition to PPP2CA, IGBP1 interacts with UBR5 and PABPC1, suggesting its involvement in multiple steps in the MTOR pathway that leads to translation initiation and cell-cycle progression
  • reduction of PPP2CA activity due to an enhanced IGBP1-PPP2CA interaction contributes directly to chemical carcinogen-induced tumorigenesis
  • STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10
  • IGBP1 interacts with MID1, a microtubule-associated ubiquitin E3 ligase that appears to regulate the function of PPP2CA
  • NMNAT2 affects MAPT phosphorylation by regulating PPP2CA activity
  • IGBP1 phosphoprotein binds to the protein phosphatase 2A catalytic subunit (PPP2CA) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible UBR5
  • in addition to recruiting PPP2CA to dephosphorylate cohesin and CDCA5, SGO1 physically shields cohesin from WAPL
  • MID1 catalyze the polyubiquitination of IGBP1, a protein regulator of protein phosphatase 2A (PPP2CA)
  • CIP2A interact with Protein phosphatase 2 (PPP2CA) to stabilize MYC and prevent its degradation
  • a significant fraction of total PPP6C is associated with IGBP1, whereas a minimal fraction of total PPP2CA is associated with IGBP1
  • oncoprotein CIP2A is stabilized via interaction with tumor suppressor PPP2CA
  • cell & other
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target
    PPP2CA and its regulatory subunits may be a therapeutic target for Alzheimer's disease
    double-transgenic Dom5/pR5 mice showed 7-fold increased numbers of hippocampal neurons that specifically phosphorylated the pathological S422 epitope of tau