| 1 | ARPP19, PPP2CA
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| The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A
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| Thapa C, Roivas P, Haataja T, Permi P, Pentikäinen U.
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| Front Mol Biosci. Mar 26;8:650881. doi: 10.3389/fmolb.2021.650881. 2021
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| 2 | IDHE, PPP2CA
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| De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.
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| Reynhout S, Jansen S, Haesen D, van Belle S, de Munnik SA, Bongers EMHF, Schieving JH, Marcelis C, Amiel J, Rio M, Mclaughlin H, Ladda R, Sell S, Kriek M, Peeters-Scholte CMPCD, Terhal PA, van Gassen KL, Verbeek N, Henry S, Scott Schwoerer J, Malik S, Revencu N, Ferreira CR, Macnamara E, Braakman HMH, Brimble E, Ruzhnikov MRZ, Wagner M, Harrer P, Wieczorek D, Kuechler A, Tziperman B, Barel O, de Vries BBA, Gordon CT, Janssens V, Vissers LELM.
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| Am J Hum Genet 104(1):139-156. doi: 10.1016/j.ajhg.2018.12.002. Epub 2018 Dec 27.
2019
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| 3 | CDC16, PPP2CA, YDJC
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| YDJC Induces Epithelial-Mesenchymal Transition via Escaping from Interaction with CDC16 through Ubiquitination of PP2A.
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| Kim EJ, Park MK, Kang GJ, Byun HJ, Kim HJ, Yu L, Kim B, Chae HS, Chin YW, Shim JG, Lee H, Lee CH.
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| J Oncol. Aug 7;2019:3542537. doi: 10.1155/2019/3542537. 2019
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| 4 | PPP2CA
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| Association between PPP2CA expression and colorectal cancer prognosis tumor marker prognostic study.
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| Yong L, YuFeng Z, Guang B.
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| Int J Surg 59:80-89. doi: 10.1016/j.ijsu.2018.09.020. Epub 2018 Oct 5.
2018
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| 5 | PPP2CA
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| Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A.
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| Ueda K, Takimoto E, Lu Q, Liu P, Fukuma N, Adachi Y, Suzuki R, Chou S, Baur W, Aronovitz MJ, Greenberg AS, Komuro I, Karas RH.
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| Diabetes 67(8):1524-1537. doi: 10.2337/db17-1342. Epub 2018 May 15.
2018
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| 6 | MASTL, PPP2CA
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| MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells
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| Yoon YN, Choe MH, Jung KY, Hwang SG, Oh JS, Kim JS.
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| BMC Cancer Jul 5;18(1):716. doi: 10.1186/s12885-018-4600-6. 2018
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| 7 | CIP2A, PPP2CA
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| Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
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| Wang J, Okkeri J, Pavic K, Wang Z, Kauko O, Halonen T, Sarek G, Ojala PM, Rao Z, Xu W, Westermarck J.
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| EMBO Rep 18(3):437-450. doi: 10.15252/embr.201642788.
2017
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| 8 | PPP2CA
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| Characterization of overexpression of the alternatively spliced isoform of the protein phosphatase 2A catalytic subunit in cells.
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| Tang S, Liu Y, Wang X, Liang Z, Cai H, Mo L, Xiao D, Guo S, Ouyang Y, Sun B, Lu C, Li X.
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| Biochem Biophys Res Commun 494(3-4):491-498. doi: 10.1016/j.bbrc.2017.10.093. Epub 2017 Oct 21.
2017
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| 9 | MAPK14, PPP2CA
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| PP2A regulates SCF-induced cardiac stem cell migration through interaction with p38 MAPK.
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| Wang Y, Xia Y, Kuang D, Duan Y, Wang G.
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| Life Sci 191:59-67. doi: 10.1016/j.lfs.2017.10.006. Epub 2017 Oct 3.
2017
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| 10 | IGBP1, PPP2CA, PPP4C
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| The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
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| LeNoue-Newton ML, Wadzinski BE, Spiller BW.
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| Biochem Biophys Res Commun 475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8.
2016
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| 11 | PPME1, PPP2CA
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| Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.
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| Kaur A, Westermarck J.
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| Biochem Soc Trans 44(6):1683-1693. Review.
2016
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| 12 | PPP2CA
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| Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells.
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| Yang D, Okamura H, Morimoto H, Teramachi J, Haneji T.
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| Lab Invest 96(10):1050-62. doi: 10.1038/labinvest.2016.82. Epub 2016 Sep 12.
2016
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| 13 | PPP2CA, PPP2R1A, RAB9A
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| A subset of RAB proteins modulates PP2A phosphatase activity.
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| Sacco F, Mattioni A, Boldt K, Panni S, Santonico E, Castagnoli L, Ueffing M, Cesareni G.
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| Sci Rep 6:32857. doi: 10.1038/srep32857.
2016
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| 14 | PPP2CA
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| PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.
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| Tang A, Shi P, Song A, Zou D, Zhou Y, Gu P, Huang Z, Wang Q, Lin Z, Gao X.
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| Cell Cycle 15(11):1450-61. doi: 10.1080/15384101.2016.1175256. Epub 2016 Apr 20.
2016
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| 15 | PPP2CA
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| Phosphatase PP2A is requisite for the function of regulatory T cells.
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| Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC.
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| Nat Immunol 17(5):556-64. doi: 10.1038/ni.3390. Epub 2016 Mar 14.
2016
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| 16 | PPP2CA
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| Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility.
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| Dudiki T, Kadunganattil S, Ferrara JK, Kline DW, Vijayaraghavan S.
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| PLoS One 10(11):e0141961. doi: 10.1371/journal.pone.0141961. eCollection 2015.
2015
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| 17 | PPP2CA
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| Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity.
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| Xian L, Hou S, Huang Z, Tang A, Shi P, Wang Q, Song A, Jiang S, Lin Z, Guo S, Gao X.
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| Aging (Albany NY) 7(4):223-32.
2015
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| 18 | ARPP19, ENSA, PPP2CA
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| The mitotic PP2A regulator ENSA/ARPP-19 is remarkably conserved across plants and most eukaryotes
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| Labandera AM, Vahab AR, Chaudhuri S, Kerk D, Moorhead GB.
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| Biochem Biophys Res Commun. Mar 20;458(4):739-44. doi: 10.1016/j.bbrc.2015.01.123. Epub 2015 Feb 7. 2015
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| 19 | IGBP1, MID1, PPP2CA
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| MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.
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| Du H, Wu K, Didoronkute A, Levy MV, Todi N, Shchelokova A, Massiah MA.
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| PLoS One 9(9):e107428. doi: 10.1371/journal.pone.0107428. eCollection 2014.
2014
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| 20 | IGBP1, PPP2CA, UBR5
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| Progestin-inducible EDD E3 ubiquitin ligase binds to α4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac.
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| McDonald WJ, Thomas LN, Koirala S, Too CK.
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| Mol Cell Endocrinol 382(1):254-61. doi: 10.1016/j.mce.2013.09.033. Epub 2013 Oct 18.
2014
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| 21 | CDCA5, PPP2CA, SGO1, WAPL
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| Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
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| Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, Yu H.
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| Nat Struct Mol Biol 21(10):864-70. doi: 10.1038/nsmb.2880. Epub 2014 Aug 31.
2014
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| 22 | CAMK1, PPME1, PPP2CA, SIK2
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| Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.
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| Lee CW, Yang FC, Chang HY, Chou H, Tan BC, Lee SC.
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| J Biol Chem 289(30):21108-19. 2014
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| 23 | GLI3, MID1, PPP2CA, STK36
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| The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu
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| Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S.
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| J Biol Chem. Nov 14;289(46):31805-31817. doi: 10.1074/jbc.M113.541219. Epub 2014 Oct 2. 2014
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| 24 | KIF7, PPFIA1, PPP2CA
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| The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.
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| Liu YC, Couzens AL, Deshwar AR, B McBroom-Cerajewski LD, Zhang X, Puviindran V, Scott IC, Gingras AC, Hui CC, Angers S.
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| Sci Signal. Dec 9;7(355):ra117. doi: 10.1126/scisignal.2005608. 2014
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| 25 | MAPT, NMNAT2, PPP2CA
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| Nmnat2 attenuates Tau phosphorylation through activation of PP2A.
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| Cheng XS, Zhao KP, Jiang X, Du LL, Li XH, Ma ZW, Yao J, Luo Y, Duan DX, Wang JZ, Zhou XW.
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| J Alzheimers Dis 36(1):185-95. doi: 10.3233/JAD-122173.
2013
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| 26 | PPP2CA
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| Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.
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| Apostolidis SA, Rauen T, Hedrich CM, Tsokos GC, Crispín JC.
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| J Biol Chem 288(37):26775-84. doi: 10.1074/jbc.M113.483743. Epub 2013 Aug 5.
2013
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| 27 | CABP4, PPP2CA
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| Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.
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| Haeseleer F, Sokal I, Gregory FD, Lee A.
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| Invest Ophthalmol Vis Sci 54(2):1214-26. doi: 10.1167/iovs.12-11319.
2013
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| 28 | IGBP1, MID1, PPP2CA
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| The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A
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| Du H, Huang Y, Zaghlula M, Walters E, Cox TC, Massiah MA.
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| J Biol Chem. Jul 19;288(29):21341-21350. doi: 10.1074/jbc.M113.481093. Epub 2013 Jun 5. 2013
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| 29 | PPP2CA, SEMA3A
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| Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation.
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| Le Guelte A, Galan-Moya EM, Dwyer J, Treps L, Kettler G, Hebda JK, Dubois S, Auffray C, Chneiweiss H, Bidere N, Gavard J.
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| J Cell Sci 125(Pt 17):4137-46. doi: 10.1242/jcs.108282. Epub 2012 Jun 8.
2012
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| 30 | GSK3B, LCMT1, PPME1, PPP2CA
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| Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
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| Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP.
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| FEBS Lett 586(16):2522-8. doi: 10.1016/j.febslet.2012.06.018. Epub 2012 Jun 22.
2012
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| 31 | FAM40A, FAM40B, MOB4, PDCD10, PPP2CA, STK26, STRN, STRN3, STRN4
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| Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization.
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| Kean MJ, Ceccarelli DF, Goudreault M, Sanches M, Tate S, Larsen B, Gibson LC, Derry WB, Scott IC, Pelletier L, Baillie GS, Sicheri F, Gingras AC.
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| J Biol Chem 286(28):25065-75. Epub 2011 May 11. 2011
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| 32 | IGBP1, MID1, PPP2CA
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| NMR studies of the C-terminus of alpha4 reveal possible mechanism of its interaction with MID1 and protein phosphatase 2A.
|
| Du H, Massiah MA.
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| PLoS One 6(12):e28877. doi: 10.1371/journal.pone.0028877. Epub 2011 Dec 14.
2011
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| 33 | IGBP1, PPP2CA
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| α4 is highly expressed in carcinogen-transformed human cells and primary human cancers.
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| Chen LP, Lai YD, Li DC, Zhu XN, Yang P, Li WX, Zhu W, Zhao J, Li XD, Xiao YM, Zhang Y, Xing XM, Wang Q, Zhang B, Lin YC, Zeng JL, Zhang SX, Liu CX, Li ZF, Zeng XW, Lin ZN, Zhuang ZX, Chen W.
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| Oncogene 30(26):2943-53. doi: 10.1038/onc.2011.20. Epub 2011 Feb 21.
2011
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| 34 | DAPK1, PPP2CA, UNC5B
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| The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
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| Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, Eisenberg-Lerner A, Shohat G, Zhang M, Laudet V, Kimchi A, Bernet A, Mehlen P.
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| Mol Cell 40(6):863-76.
2010
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| 35 | IL23A, PPP2CA
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| Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A.
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| Chang J, Voorhees TJ, Liu Y, Zhao Y, Chang CH.
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| Proc Natl Acad Sci U S A 107(18):8340-5. doi: 10.1073/pnas.0914703107. Epub 2010 Apr 19.
2010
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| 36 | IGBP1, PABPC1, PPP2CA, UBR5
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| alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein.
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| McDonald WJ, Sangster SM, Moffat LD, Henderson MJ, Too CK.
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| J Cell Biochem 110(5):1123-9. doi: 10.1002/jcb.22624.
2010
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| 37 | PPP2CA
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| Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers.
|
| Sheth P, Samak G, Shull JA, Seth A, Rao R.
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| Biochem J 421(1):59-70.PMID: 19356149 2009
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| 38 | PPP2CA
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| Substrate-specific reduction of PP2A activity exaggerates tau pathology.
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| Deters N, Ittner LM, Götz J.
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| Biochem Biophys Res Commun 379(2):400-5. Epub 2009 Jan 4.PMID: 19126401 2009
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| 39 | FAM40A, FAM40B, MOB4, PDCD10, PPP2CA, STRN, STRN3, STRN4
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| A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
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| Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC.
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| Mol Cell Proteomics 8(1):157-71. Epub 2008 Sep 8.
2009
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| 40 | IGBP1, PPP2CA
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| Alpha4 is an essential regulator of PP2A phosphatase activity.
|
| Kong M, Ditsworth D, Lindsten T, Thompson CB.
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| Mol Cell 36(1):51-60. doi: 10.1016/j.molcel.2009.09.025.
2009
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| 41 | KISS1R, PPP2CA
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| Physical association of GPR54 C-terminal with protein phosphatase 2A.
|
| Evans BJ, Wang Z, Mobley L, Khosravi D, Fujii N, Navenot JM, Peiper SC.
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| Biochem Biophys Res Commun 377(4):1067-71. Epub 2008 Oct 31. 2008
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| 42 | PPP2CA, SPHK1
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| Deactivation of sphingosine kinase 1 by protein phosphatase 2A.
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| Barr RK, Lynn HE, Moretti PA, Khew-Goodall Y, Pitson SM.
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| J Biol Chem 283(50):34994-5002. Epub 2008 Oct 13.PMID: 18852266 2008
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| 43 | FCAR, PPP2CA
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| Inside-out regulation of Fc alpha RI (CD89) depends on PP2A.
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| Bakema JE, Bakker A, de Haij S, Honing H, Bracke M, Koenderman L, Vidarsson G, van de Winkel JG, Leusen JH.
|
| J Immunol 181(6):4080-8.
2008
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| 44 | ILKAP, PHLPP1, PPP2CA, PPP2CB
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| Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling.
|
| Lammers T, Lavi S.
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| Crit Rev Biochem Mol Biol 42(6):437-61. Review.PMID: 18066953 2007
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| 45 | PPP2CA, PPP2CB, GRM3
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| Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.
|
| Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P.
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| Proc Natl Acad Sci U S A 100(26):16006-11. Epub 2003 Dec 08. 2003
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| 46 | PPP2CA
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| The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.
|
| Gotz J, Kues W.
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| Biol Chem 380(9):1117-20. 1999
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| 47 | PPP2CA
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| Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
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| De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J.
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| Biochemistry 38(50):16539-47. 1999
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| 48 | PPP2CA, PPP2CB, PPP2CBP
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| Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-q31 and 8p12-p11.2, respectively.
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| Jones TA, et al.
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| Cytogenet Cell Genet 63 : 35-41. 1993
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| 49 | PPP2CA
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| Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.
|
| Khew-Goodall Y, Mayer RE, Maurer F, Stone SR, Hemmings BA.
|
| Biochemistry 30(1):89-97. Erratum in: Biochemistry 1991 May 28;30(21):5328. PMID: 1846293 1991
|