Citations for
1IDHE, PPP2CA
De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.
Reynhout S, Jansen S, Haesen D, van Belle S, de Munnik SA, Bongers EMHF, Schieving JH, Marcelis C, Amiel J, Rio M, Mclaughlin H, Ladda R, Sell S, Kriek M, Peeters-Scholte CMPCD, Terhal PA, van Gassen KL, Verbeek N, Henry S, Scott Schwoerer J, Malik S, Revencu N, Ferreira CR, Macnamara E, Braakman HMH, Brimble E, Ruzhnikov MRZ, Wagner M, Harrer P, Wieczorek D, Kuechler A, Tziperman B, Barel O, de Vries BBA, Gordon CT, Janssens V, Vissers LELM.
Am J Hum Genet 104(1):139-156. doi: 10.1016/j.ajhg.2018.12.002. Epub 2018 Dec 27. 2019
2CDC16, PPP2CA, YDJC
YDJC Induces Epithelial-Mesenchymal Transition via Escaping from Interaction with CDC16 through Ubiquitination of PP2A.
Kim EJ, Park MK, Kang GJ, Byun HJ, Kim HJ, Yu L, Kim B, Chae HS, Chin YW, Shim JG, Lee H, Lee CH.
J Oncol. Aug 7;2019:3542537. doi: 10.1155/2019/3542537. 2019
3PPP2CA
Association between PPP2CA expression and colorectal cancer prognosis tumor marker prognostic study.
Yong L, YuFeng Z, Guang B.
Int J Surg 59:80-89. doi: 10.1016/j.ijsu.2018.09.020. Epub 2018 Oct 5. 2018
4PPP2CA
Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A.
Ueda K, Takimoto E, Lu Q, Liu P, Fukuma N, Adachi Y, Suzuki R, Chou S, Baur W, Aronovitz MJ, Greenberg AS, Komuro I, Karas RH.
Diabetes 67(8):1524-1537. doi: 10.2337/db17-1342. Epub 2018 May 15. 2018
5CIP2A, PPP2CA
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
Wang J, Okkeri J, Pavic K, Wang Z, Kauko O, Halonen T, Sarek G, Ojala PM, Rao Z, Xu W, Westermarck J.
EMBO Rep 18(3):437-450. doi: 10.15252/embr.201642788. 2017
6PPP2CA
Characterization of overexpression of the alternatively spliced isoform of the protein phosphatase 2A catalytic subunit in cells.
Tang S, Liu Y, Wang X, Liang Z, Cai H, Mo L, Xiao D, Guo S, Ouyang Y, Sun B, Lu C, Li X.
Biochem Biophys Res Commun 494(3-4):491-498. doi: 10.1016/j.bbrc.2017.10.093. Epub 2017 Oct 21. 2017
7MAPK14, PPP2CA
PP2A regulates SCF-induced cardiac stem cell migration through interaction with p38 MAPK.
Wang Y, Xia Y, Kuang D, Duan Y, Wang G.
Life Sci 191:59-67. doi: 10.1016/j.lfs.2017.10.006. Epub 2017 Oct 3. 2017
8IGBP1, PPP2CA, PPP4C
The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
LeNoue-Newton ML, Wadzinski BE, Spiller BW.
Biochem Biophys Res Commun 475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8. 2016
9PPME1, PPP2CA
Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.
Kaur A, Westermarck J.
Biochem Soc Trans 44(6):1683-1693. Review. 2016
10PPP2CA
Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells.
Yang D, Okamura H, Morimoto H, Teramachi J, Haneji T.
Lab Invest 96(10):1050-62. doi: 10.1038/labinvest.2016.82. Epub 2016 Sep 12. 2016
11PPP2CA, PPP2R1A, RAB9A
A subset of RAB proteins modulates PP2A phosphatase activity.
Sacco F, Mattioni A, Boldt K, Panni S, Santonico E, Castagnoli L, Ueffing M, Cesareni G.
Sci Rep 6:32857. doi: 10.1038/srep32857. 2016
12PPP2CA
PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.
Tang A, Shi P, Song A, Zou D, Zhou Y, Gu P, Huang Z, Wang Q, Lin Z, Gao X.
Cell Cycle 15(11):1450-61. doi: 10.1080/15384101.2016.1175256. Epub 2016 Apr 20. 2016
13PPP2CA
Phosphatase PP2A is requisite for the function of regulatory T cells.
Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC.
Nat Immunol 17(5):556-64. doi: 10.1038/ni.3390. Epub 2016 Mar 14. 2016
14PPP2CA
Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility.
Dudiki T, Kadunganattil S, Ferrara JK, Kline DW, Vijayaraghavan S.
PLoS One 10(11):e0141961. doi: 10.1371/journal.pone.0141961. eCollection 2015. 2015
15PPP2CA
Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity.
Xian L, Hou S, Huang Z, Tang A, Shi P, Wang Q, Song A, Jiang S, Lin Z, Guo S, Gao X.
Aging (Albany NY) 7(4):223-32. 2015
16IGBP1, MID1, PPP2CA
MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.
Du H, Wu K, Didoronkute A, Levy MV, Todi N, Shchelokova A, Massiah MA.
PLoS One 9(9):e107428. doi: 10.1371/journal.pone.0107428. eCollection 2014. 2014
17IGBP1, PPP2CA, UBR5
Progestin-inducible EDD E3 ubiquitin ligase binds to α4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac.
McDonald WJ, Thomas LN, Koirala S, Too CK.
Mol Cell Endocrinol 382(1):254-61. doi: 10.1016/j.mce.2013.09.033. Epub 2013 Oct 18. 2014
18CDCA5, PPP2CA, SGO1, WAPL
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, Yu H.
Nat Struct Mol Biol 21(10):864-70. doi: 10.1038/nsmb.2880. Epub 2014 Aug 31. 2014
19PPME1, PPP2CA, SIK2
Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.
Lee CW, Yang FC, Chang HY, Chou H, Tan BC, Lee SC.
J Biol Chem 289(30):21108-19. 2014
20GLI3, MID1, PPP2CA, STK36
The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu
Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S.
J Biol Chem. Nov 14;289(46):31805-31817. doi: 10.1074/jbc.M113.541219. Epub 2014 Oct 2. 2014
21KIF7, PPFIA1, PPP2CA
The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.
Liu YC, Couzens AL, Deshwar AR, B McBroom-Cerajewski LD, Zhang X, Puviindran V, Scott IC, Gingras AC, Hui CC, Angers S.
Sci Signal. Dec 9;7(355):ra117. doi: 10.1126/scisignal.2005608. 2014
22MAPT, NMNAT2, PPP2CA
Nmnat2 attenuates Tau phosphorylation through activation of PP2A.
Cheng XS, Zhao KP, Jiang X, Du LL, Li XH, Ma ZW, Yao J, Luo Y, Duan DX, Wang JZ, Zhou XW.
J Alzheimers Dis 36(1):185-95. doi: 10.3233/JAD-122173. 2013
23PPP2CA
Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.
Apostolidis SA, Rauen T, Hedrich CM, Tsokos GC, Crispín JC.
J Biol Chem 288(37):26775-84. doi: 10.1074/jbc.M113.483743. Epub 2013 Aug 5. 2013
24CABP4, PPP2CA
Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.
Haeseleer F, Sokal I, Gregory FD, Lee A.
Invest Ophthalmol Vis Sci 54(2):1214-26. doi: 10.1167/iovs.12-11319. 2013
25IGBP1, MID1, PPP2CA
The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A
Du H, Huang Y, Zaghlula M, Walters E, Cox TC, Massiah MA.
J Biol Chem. Jul 19;288(29):21341-21350. doi: 10.1074/jbc.M113.481093. Epub 2013 Jun 5. 2013
26PPP2CA, SEMA3A
Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation.
Le Guelte A, Galan-Moya EM, Dwyer J, Treps L, Kettler G, Hebda JK, Dubois S, Auffray C, Chneiweiss H, Bidere N, Gavard J.
J Cell Sci 125(Pt 17):4137-46. doi: 10.1242/jcs.108282. Epub 2012 Jun 8. 2012
27GSK3B, LCMT1, PPME1, PPP2CA
Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP.
FEBS Lett 586(16):2522-8. doi: 10.1016/j.febslet.2012.06.018. Epub 2012 Jun 22. 2012
28FAM40A, FAM40B, MOB4, PDCD10, PPP2CA, STK26, STRN, STRN3, STRN4
Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization.
Kean MJ, Ceccarelli DF, Goudreault M, Sanches M, Tate S, Larsen B, Gibson LC, Derry WB, Scott IC, Pelletier L, Baillie GS, Sicheri F, Gingras AC.
J Biol Chem 286(28):25065-75. Epub 2011 May 11. 2011
29IGBP1, MID1, PPP2CA
NMR studies of the C-terminus of alpha4 reveal possible mechanism of its interaction with MID1 and protein phosphatase 2A.
Du H, Massiah MA.
PLoS One 6(12):e28877. doi: 10.1371/journal.pone.0028877. Epub 2011 Dec 14. 2011
30IGBP1, PPP2CA
α4 is highly expressed in carcinogen-transformed human cells and primary human cancers.
Chen LP, Lai YD, Li DC, Zhu XN, Yang P, Li WX, Zhu W, Zhao J, Li XD, Xiao YM, Zhang Y, Xing XM, Wang Q, Zhang B, Lin YC, Zeng JL, Zhang SX, Liu CX, Li ZF, Zeng XW, Lin ZN, Zhuang ZX, Chen W.
Oncogene 30(26):2943-53. doi: 10.1038/onc.2011.20. Epub 2011 Feb 21. 2011
31DAPK1, PPP2CA, UNC5B
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, Eisenberg-Lerner A, Shohat G, Zhang M, Laudet V, Kimchi A, Bernet A, Mehlen P.
Mol Cell 40(6):863-76. 2010
32IL23A, PPP2CA
Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A.
Chang J, Voorhees TJ, Liu Y, Zhao Y, Chang CH.
Proc Natl Acad Sci U S A 107(18):8340-5. doi: 10.1073/pnas.0914703107. Epub 2010 Apr 19. 2010
33IGBP1, PABPC1, PPP2CA, UBR5
alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein.
McDonald WJ, Sangster SM, Moffat LD, Henderson MJ, Too CK.
J Cell Biochem 110(5):1123-9. doi: 10.1002/jcb.22624. 2010
34PPP2CA
Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers.
Sheth P, Samak G, Shull JA, Seth A, Rao R.
Biochem J 421(1):59-70.PMID: 19356149 2009
35PPP2CA
Substrate-specific reduction of PP2A activity exaggerates tau pathology.
Deters N, Ittner LM, Götz J.
Biochem Biophys Res Commun 379(2):400-5. Epub 2009 Jan 4.PMID: 19126401 2009
36FAM40A, FAM40B, MOB4, PDCD10, PPP2CA, STRN, STRN3, STRN4
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC.
Mol Cell Proteomics 8(1):157-71. Epub 2008 Sep 8. 2009
37IGBP1, PPP2CA
Alpha4 is an essential regulator of PP2A phosphatase activity.
Kong M, Ditsworth D, Lindsten T, Thompson CB.
Mol Cell 36(1):51-60. doi: 10.1016/j.molcel.2009.09.025. 2009
38KISS1R, PPP2CA
Physical association of GPR54 C-terminal with protein phosphatase 2A.
Evans BJ, Wang Z, Mobley L, Khosravi D, Fujii N, Navenot JM, Peiper SC.
Biochem Biophys Res Commun 377(4):1067-71. Epub 2008 Oct 31. 2008
39PPP2CA, SPHK1
Deactivation of sphingosine kinase 1 by protein phosphatase 2A.
Barr RK, Lynn HE, Moretti PA, Khew-Goodall Y, Pitson SM.
J Biol Chem 283(50):34994-5002. Epub 2008 Oct 13.PMID: 18852266 2008
40FCAR, PPP2CA
Inside-out regulation of Fc alpha RI (CD89) depends on PP2A.
Bakema JE, Bakker A, de Haij S, Honing H, Bracke M, Koenderman L, Vidarsson G, van de Winkel JG, Leusen JH.
J Immunol 181(6):4080-8. 2008
41ILKAP, PHLPP1, PPP2CA, PPP2CB
Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling.
Lammers T, Lavi S.
Crit Rev Biochem Mol Biol 42(6):437-61. Review.PMID: 18066953 2007
42PPP2CA, PPP2CB, GRM3
Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.
Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P.
Proc Natl Acad Sci U S A 100(26):16006-11. Epub 2003 Dec 08. 2003
43PPP2CA
The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.
Gotz J, Kues W.
Biol Chem 380(9):1117-20. 1999
44PPP2CA
Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J.
Biochemistry 38(50):16539-47. 1999
45PPP2CA, PPP2CB, PPP2CBP
Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-q31 and 8p12-p11.2, respectively.
Jones TA, et al.
Cytogenet Cell Genet 63 : 35-41. 1993
46PPP2CA
Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.
Khew-Goodall Y, Mayer RE, Maurer F, Stone SR, Hemmings BA.
Biochemistry 30(1):89-97. Erratum in: Biochemistry 1991 May 28;30(21):5328. PMID: 1846293 1991