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FLASH GENE
Symbol PPP1R16A contributors: mct/ - updated : 26-06-2012
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 16A
HGNC id 14941
Location 8q24.3      Physical location : 145.722.108 - 145.727.503
Synonym name
  • myosin phosphatase targeting subunit 3
  • Synonym symbol(s) MYPT3, MGC14333, R16A
    DNA
    TYPE functioning gene
    STRUCTURE 5.66 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse) DKFZp547F072 8q24.3 hypothetical protein DKFZp547F072 SCRT1 8q24.3 scratch homolog 1, zinc finger protein (Drosophila) LOC340393 8q24.3 similar to unnmaed protein product FBXL6 8q24-q25 F-box and leucine-rich repeat protein 6 FLJ11856 8q24.3 putative G-protein coupled receptor GPCR41 ADCK5 8q24.3 aarF domain containing kinase 5 CPSF1 8q24-q23 cleavage and polyadenylation specific factor 1, 160kDa SLC39A4 8q24.3 solute carrier family 39 (zinc transporter), member 4 VPS28 8q24.3 vacuolar protein sorting 28 (yeast) NFKBIL2 8q24.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 MGC13010 8q24.3 hypothetical protein MGC13010 KIFC2 8q24.3 likely ortholog of mouse kinesin family member C2 FOXH1 8q24.3 forkhead box H1 PPP1R16A 8q24.3 protein phosphatase 1, regulatory (inhibitor) subunit 16A GPT 8q24.3 glutamic-pyruvate transaminase (alanine aminotransferase) LOC113655 8q24.3 hypothetical protein BC011982 RECQL4 8q24.3 RecQ protein-like 4 KIAA0014 8q24.3 RecQ protein-like 4 LOC389698 8 LOC389698 KIAA1688 8q24.3 KIAA1688 protein LOC90987 MGC10520 RPL8 8q24.3-qter ribosomal protein L8 ZNF517 8q24.3 zinc finger protein 517
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2326 - 528 - 2008 18202305
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly Homo sapiens
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ankyrin repeats at the N terminus and a consensus PP1-binding site, binding OAZ3 p12
  • a unique C terminal region containing several potential signaling motifs and a CaaX prenylation site (where AA indicates aliphatic amino acid) box at the C termini
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Ppp1r16a
    Homologene
    FAMILY
  • myosin phosphatase targeting subunit (MYPT) family
  • nuclear steroid/thyroid hormone receptor family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • myosin-binding targeting subunits of protein phosphatase 1 (PPP1c)
  • its phosphorylation may play an important role in regulating PP1c catalytic activity
  • constitutive active/androstane receptor-binding protein
  • may mediate the phenobarbital signal to initiate constitutive active/androstane receptor nuclear translocation, through a mechanism including its dimerization and inhibition of PP1beta activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • can form dimer through its middle region, where protein kinase A phosphorylation sites are recently identified
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • can be a substrate for protein kinase A (PRKACA)
  • can bind protein phosphatase PPP1CC, the only protein phosphatase present in sperm tails, and p12- PPP1R16A interaction modulates the activity of PPP1CC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS