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FLASH GENE
Symbol PPP1R16A contributors: mct/ - updated : 26-06-2012
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 16A
HGNC id 14941
DNA
TYPE functioning gene
STRUCTURE 5.66 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2326 - 528 - 2008 18202305
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly Homo sapiens
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivesperm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ankyrin repeats at the N terminus and a consensus PP1-binding site, binding OAZ3 p12
  • a unique C terminal region containing several potential signaling motifs and a CaaX prenylation site (where AA indicates aliphatic amino acid) box at the C termini
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Ppp1r16a
    Homologene
    FAMILY
  • myosin phosphatase targeting subunit (MYPT) family
  • nuclear steroid/thyroid hormone receptor family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • myosin-binding targeting subunits of protein phosphatase 1 (PPP1c)
  • its phosphorylation may play an important role in regulating PP1c catalytic activity
  • constitutive active/androstane receptor-binding protein
  • may mediate the phenobarbital signal to initiate constitutive active/androstane receptor nuclear translocation, through a mechanism including its dimerization and inhibition of PP1beta activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • can form dimer through its middle region, where protein kinase A phosphorylation sites are recently identified
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • can be a substrate for protein kinase A (PRKACA)
  • can bind protein phosphatase PPP1CC, the only protein phosphatase present in sperm tails, and p12- PPP1R16A interaction modulates the activity of PPP1CC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS