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FLASH GENE

Symbol

PPP1R16A

contributors: mct/ - updated : 26-06-2012

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 16A
HGNC id	14941

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ankyrin repeats at the N terminus and a consensus PP1-binding site, binding OAZ3 p12
	a unique C terminal region containing several potential signaling motifs and a CaaX prenylation site (where AA indicates aliphatic amino acid) box at the C termini

mono polymer

dimer

HOMOLOGY

interspecies

homolog to murine Ppp1r16a

Homologene

FAMILY	myosin phosphatase targeting subunit (MYPT) family
	nuclear steroid/thyroid hormone receptor family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	myosin-binding targeting subunits of protein phosphatase 1 (PPP1c)
	its phosphorylation may play an important role in regulating PP1c catalytic activity
	constitutive active/androstane receptor-binding protein
	may mediate the phenobarbital signal to initiate constitutive active/androstane receptor nuclear translocation, through a mechanism including its dimerization and inhibition of PP1beta activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

can form dimer through its middle region, where protein kinase A phosphorylation sites are recently identified

INTERACTION

DNA

RNA

small molecule

protein	PP1
	can be a substrate for protein kinase A (PRKACA)
	can bind protein phosphatase PPP1CC, the only protein phosphatase present in sperm tails, and p12- PPP1R16A interaction modulates the activity of PPP1CC

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS