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FLASH GENE
Symbol PPIP5K1 contributors: mct - updated : 07-05-2012
HGNC name diphosphoinositol pentakisphosphate kinase 1
HGNC id 29023
Location 15q15.3      Physical location : 43.825.659 - 43.882.451
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, related to S cerevisiae protein YLR410W
  • hypothetical protein LOC9677
  • inositol pyrophosphate synthase 1
  • PP-IP5 kinase 1
  • IP6 kinase
  • histidine acid phosphatase domain containing 2A
    • Synonym symbol(s) KIAA0377, MGC51871, IP6K, IPS1, VIP1, HISPPD2A, DKFZp313L0221
    EC.number 2.7.4.1, 2.7.4.24
    DNA
    TYPE functioning gene
    STRUCTURE 56.79 kb     35 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 splicing 5564 156.5 1408 - 2009 18981179
  • isoform 2
    • 28 splicing 4920 133.4 1194 - 2009 18981179
  • isoform 4
    • 29 - 5641 - 1408 - 2009 18981179
    30 - 5640 - 1406 - 2009 18981179
    31 - 5721 - 1433 - 2009 18981179
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
     respiratory tractlarynx   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal kinase domain
  • a phosphatase-like domain of unknown significance
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Hisppd2a (91.2pc)
    Homologene
    FAMILY histidine acid phosphatase family, VIP1 subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • phosphorylating IP6 to produce IP7 and also able to convert IP7 to IP8
  • requires TRAF6 and MAP3K1 to activate NF-kappaB and mitogen-activated protein kinases that are critical for the optimal induction of type I interferons (Yoshida 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism alcohol
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by exposure to hyperosmotic stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS