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FLASH GENE
Symbol PPIP5K1 contributors: mct - updated : 07-05-2012
HGNC name diphosphoinositol pentakisphosphate kinase 1
HGNC id 29023
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal kinase domain
  • a phosphatase-like domain of unknown significance
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Hisppd2a (91.2pc)
    Homologene
    FAMILY histidine acid phosphatase family, VIP1 subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • phosphorylating IP6 to produce IP7 and also able to convert IP7 to IP8
  • requires TRAF6 and MAP3K1 to activate NF-kappaB and mitogen-activated protein kinases that are critical for the optimal induction of type I interferons (Yoshida 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism alcohol
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by exposure to hyperosmotic stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS