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FLASH GENE
Symbol PPIP5K1 contributors: mct - updated : 07-05-2012
HGNC name diphosphoinositol pentakisphosphate kinase 1
HGNC id 29023
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemtestis   
Respiratorylung    
 respiratory tractlarynx   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal kinase domain
  • a phosphatase-like domain of unknown significance
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Hisppd2a (91.2pc)
    Homologene
    FAMILY histidine acid phosphatase family, VIP1 subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • phosphorylating IP6 to produce IP7 and also able to convert IP7 to IP8
  • requires TRAF6 and MAP3K1 to activate NF-kappaB and mitogen-activated protein kinases that are critical for the optimal induction of type I interferons (Yoshida 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism alcohol
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by exposure to hyperosmotic stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS