Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol POP1 contributors: mct - updated : 30-04-2013
HGNC name processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
HGNC id 30129
Corresponding disease
SMDA2 spondylometaphyseal dysplasia anauxetic type 2
Location 8q22.2      Physical location : 99.129.520 - 99.172.068
Synonym symbol(s) KIAA0061
EC.number 3.1.26.5
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
text HRSP12 and POP1 are oriented head-to-head, separated by a 102-bp region containing a bidirectional promoter
STRUCTURE 42.55 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392254 8 similar to glyceraldehyde-3-phosphate dehydrogenase LOC392255 8 similar to growth and differentiation factor 6 UQCRB 8q22 ubiquinol-cytochrome c reductase binding protein CGI-12 8q22.1 CGI-12 protein PTDSS1 8q22 phosphatidylserine synthase 1 SDC2 8q22-q23 syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) PGCP 8q22.2 plasma glutamate carboxypeptidase KIAA1750 8q22.1 KIAA1750 protein LOC286150 8q22.1 similar to 40S ribosomal protein S2 LYRIC 8q22.1 LYRIC/3D3 LAPTM4B 8q22.1 lysosomal associated protein transmembrane 4 beta LOC389678 8 similar to hypothetical protein LOC51249 RPS23P1 8q23 ribosomal protein S23 pseudogene 1 MATN2 8q22 matrilin 2 RPL30 8q22-q24 ribosomal protein L30 FLJ39553 8q22.2 hypothetical protein FLJ39553 UK114 8q22 hypothetical protein FLJ39553 POP1 8q22.1 processing of precursors 1 FLJ13955 8q22.2 hypothetical protein FLJ13955 KCNS2 8q23.3-q24.11 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 STK3 8q22.2 serine/threonine kinase 3 (STE20 homolog, yeast) MRP63P7 8q22.2 mitochondrial ribosomal protein 63 pseudogene 7 OSR2 8q22.2 odd-skipped-related 2A protein COH1 8q22.2 Cohen syndrome 1 COX6C 8q22-q23 cytochrome c oxidase subunit VIc DKFZP434I092 8q22.3 DKFZP434I092 protein LOC286151 8q22.3 similar to RIKEN cDNA 4930533G20 POLR2K 8q22 polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa SPAG1 8q22 sperm associated antigen 1 RNF19 8q22 ring finger protein 19 LOC157567 8q22.3 hypothetical protein LOC157567
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4761 - 1024 - -
16 - 4701 - 1024 - -
16 - 4689 - 1024 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
Reproductivefemale systemuteruscervix predominantly
Skin/Tegumentskin   highly
Urinarybladder   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated RiboP
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Pop1
Homologene
FAMILY small nucleolar ribonucleoprotein (snoRNP) particles
CATEGORY enzyme , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • involved in a protein complex that generates mature tRNA molecules by cleaving their 5'ends
  • endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor
  • cleaving RNA derived from the mitochondrial origin of DNA replication
  • implicated in pre-rRNA processing
  • plays multiple roles in the assembly and function of RNases P and mitochondrial RNA processing, and the functions can be differentiated through the mutations in conserved residues
  • core component of the RNase mitochondrial RNA processing (RNase MRP) complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • tRNA catabolism
  • a component
  • nucleolar ribonuclease P complex
  • ribonuclease MRP complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with the RMRP RNA domains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SMDA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS