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FLASH GENE
Symbol POP1 contributors: mct - updated : 30-04-2013
HGNC name processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
HGNC id 30129
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
Reproductivefemale systemuteruscervix predominantly
Skin/Tegumentskin   highly
Urinarybladder   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated RiboP
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Pop1
Homologene
FAMILY small nucleolar ribonucleoprotein (snoRNP) particles
CATEGORY enzyme , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • involved in a protein complex that generates mature tRNA molecules by cleaving their 5'ends
  • endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor
  • cleaving RNA derived from the mitochondrial origin of DNA replication
  • implicated in pre-rRNA processing
  • plays multiple roles in the assembly and function of RNases P and mitochondrial RNA processing, and the functions can be differentiated through the mutations in conserved residues
  • core component of the RNase mitochondrial RNA processing (RNase MRP) complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • tRNA catabolism
  • a component
  • nucleolar ribonuclease P complex
  • ribonuclease MRP complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with the RMRP RNA domains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SMDA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS