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FLASH GENE
Symbol POP1 contributors: mct - updated : 30-04-2013
HGNC name processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
HGNC id 30129
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4761 - 1024 - -
16 - 4701 - 1024 - -
16 - 4689 - 1024 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
Reproductivefemale systemuteruscervix predominantly
Skin/Tegumentskin   highly
Urinarybladder   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated RiboP
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Pop1
Homologene
FAMILY small nucleolar ribonucleoprotein (snoRNP) particles
CATEGORY enzyme , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • involved in a protein complex that generates mature tRNA molecules by cleaving their 5'ends
  • endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor
  • cleaving RNA derived from the mitochondrial origin of DNA replication
  • implicated in pre-rRNA processing
  • plays multiple roles in the assembly and function of RNases P and mitochondrial RNA processing, and the functions can be differentiated through the mutations in conserved residues
  • core component of the RNase mitochondrial RNA processing (RNase MRP) complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • tRNA catabolism
  • a component
  • nucleolar ribonuclease P complex
  • ribonuclease MRP complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with the RMRP RNA domains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SMDA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS