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FLASH GENE
Symbol PON3 contributors: npt/ - updated : 14-02-2006
HGNC name paraoxonase 3
HGNC id 9206
Location 7q21.3      Physical location : 94.989.185 - 95.025.687
Synonym name
  • serum aryldiakylphosphatase 3
  • paraoxonase-like sequence 2 (PON3)
  • serum paraoxonase/lactonase 3
    • EC.number 3.1.1.2, 3.1.8.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 36.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1201 - 354 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Pou3
    Homologene
    FAMILY
  • paraoxonase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but not regulated by oxidized lipids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to coronary heart disease
  • to Alzheimer disease (AD)
    • Variant & Polymorphism multiple variants in PON influence serum paraoxonase activity, and low serum paraoxonase activity is a risk factor for AD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS