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FLASH GENE
Symbol PON3 contributors: npt/ - updated : 14-02-2006
HGNC name paraoxonase 3
HGNC id 9206
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Pou3
Homologene
FAMILY
  • paraoxonase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but not regulated by oxidized lipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to coronary heart disease
  • to Alzheimer disease (AD)
  • Variant & Polymorphism multiple variants in PON influence serum paraoxonase activity, and low serum paraoxonase activity is a risk factor for AD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS