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FLASH GENE
Symbol PON3 contributors: npt/ - updated : 14-02-2006
HGNC name paraoxonase 3
HGNC id 9206
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Pou3
Homologene
FAMILY
  • paraoxonase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but not regulated by oxidized lipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to coronary heart disease
  • to Alzheimer disease (AD)
  • Variant & Polymorphism multiple variants in PON influence serum paraoxonase activity, and low serum paraoxonase activity is a risk factor for AD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS