SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,cytoplasm,cytosolic,microsome
|
text
| predominant PON2 association with microsomes and lysosomes in the human jejunum (Levy 2007) |
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localization to the ER in endothelial cells (Stoltzl 2009) |
basic FUNCTION
| acting as a cellular antioxidant, protecting cells from oxidative stress |
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attenuates macrophage triglyceride accumulation and foam cell formation via inhibition of microsomal DGAT1 activity, which appears to be sensitive to oxidative state (Rosenblat 2009) |
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macrophage PON2 expression is upregulated in unesterified cholesterol-enriched macrophages through activation of the PI(3)K signal pathway (Shiner 2007) |
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having protective effects against prooxidant stimuli in the small intestine (Levy 2007) |
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attenuated macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase |
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having a lactonase activity that may play a role in innate immunity, atherosclerosis (Stoltz 2009) |
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effectively rescues PARK7 deficiency-mediated hypersensitivity to oxidative stress |