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FLASH GENE
Symbol POLR2B contributors: mct - updated : 24-08-2012
HGNC name polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
HGNC id 9188
Location 4q12      Physical location : 57.845.108 - 57.897.334
Synonym name
  • subunit 2, RNA polymerase II second largest subunit
  • RNA polymerase II subunit B2
  • Synonym symbol(s) RPB2, HRPB140, POL2RB, hsRPB2
    EC.number 2.7.7.6
    DNA
    TYPE functioning gene
    STRUCTURE 52.23 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    GCPHLP 4q12 likely ortholog of mouse germ cell-specific phosphoducin-like protein Mgcphlp NMU 4q12 neuromedin U SEC3 FLJ13621 4q12 hypothetical protein FLJ13621 KIAA0635 4q12-q13.3 hypothetical protein FLJ13621 KIAA1211 4q12 KIAA1211 protein MRPL22P1 4q12 KIAA1211 protein NRPS998 4q12 2-aminoadipic 6-semialdehyde dehydrogenase PPAT 4q12 phosphoribosyl pyrophosphate amidotransferase PAICS 4q12 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase SRP72 1q32 signal recognition particle 72kDa LOC132946 4q12 similar to MGC69138 protein LOC391654 4 LOC391654 GLDCP 4q12 glycine dehydrogenase (decarboxylase) pseudogene HOP 4q11-q12 homeodomain-only protein LOC391655 4 similar to 60S ribosomal protein L17 (L23) LOC285453 4q12 similar to APACD protein SPINK2 4q12 serine protease inhibitor, Kazal type, 2 (acrosin-trypsin inhibitor) REST 4q12 RE1-silencing transcription factor MGC3232 POLR2B 4q12 polymerase (RNA) II (DNA directed) polypeptide B, 140kDa IGFBP7 4q12 insulin-like growth factor binding protein 7 LOC255130 4q12 hypothetical LOC255130 SRIL 4pter-p16.2 sorcin-like
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3748 133.8 1174 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
    Reproductivefemale systemuterus  highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C4-type zinc finger domain
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to rattus Polr2b (100 pc)
    homolog to murine Polr2b (99.9 pc)
    Homologene
    FAMILY
  • RNA polymerase beta chain family
  • CATEGORY enzyme , RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • catalizing the transcription of DNA into RNA using the 4 ribonucleoside triphosphate as substrates
  • proposed to contribute to the polymerase catalytic activity
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • 10 to 14 subunits from 220 to 7 kDa
  • second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs
  • forming the polymerase active center together with the largest subunit
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    inactivated in renal clear cell carcinomas with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS