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FLASH GENE

Symbol

POLR2B

contributors: mct - updated : 24-08-2012

HGNC name	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
HGNC id	9188

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Nervous brain       moderately Reproductive female system uterus     highly   male system testis     highly Respiratory respiratory tract trachea     predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a C4-type zinc finger domain

mono polymer

heteromer , complex

HOMOLOGY

interspecies	homolog to rattus Polr2b (100 pc)
	homolog to murine Polr2b (99.9 pc)

Homologene

FAMILY

RNA polymerase beta chain family

CATEGORY

enzyme , RNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	catalizing the transcription of DNA into RNA using the 4 ribonucleoside triphosphate as substrates
	proposed to contribute to the polymerase catalytic activity

CELLULAR PROCESS	nucleotide, replication
	nucleotide, transcription, elongation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	10 to 14 subunits from 220 to 7 kDa
	second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs
	forming the polymerase active center together with the largest subunit

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+
	Mg2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function inactivated in renal clear cell carcinomas with poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS