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FLASH GENE
Symbol PODXL contributors: mct/shn - updated : 17-03-2011
HGNC name podocalyxin-like
HGNC id 9171
Location 7q32.3      Physical location : 131.185.022 - 131.241.376
Synonym name
  • keratan sulfate (KS) proteoglycan
  • GCTM-2 antigen
  • podocalyxin
  • podocalyxin-like protein 1
  • Synonym symbol(s) PCLP, Gp200, GCTM-2, PC, MGC138240, PCLP-1
    DNA
    TYPE functioning gene
    STRUCTURE 56.36 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D7S3054 - D7S2531- PODXL - D7S512 - D7S1804 - qter
    Physical map
    LOC389556 7 LOC389556 FLJ14803 7q32.3 hypothetical protein FLJ14803 LOC136263 7q32.3 LOC136263 CPA2 7q32 carboxypeptidase A2 (pancreatic) CPA4 7q32 carboxypeptidase A4 CPA5 7q32 carboxypeptidase A5 CPA1 7q32 carboxypeptidase A1 (pancreatic) TSGA14 7q32 testis specific, 14 MEST 7q32 mesoderm specific transcript homolog (mouse) COPG2 7q32 coatomer protein complex, subunit gamma 2 TSGA13 7q32 testis specific, 13 KLF14 7q32.3 Kruppel-like factor 14 LOC347674 7q32 ALEX2 pseudogene LOC340349 7q32.3 hypothetical LOC340349 FLJ43663 7q32.3 hypothetical protein FLJ43663 LOC136256 7q32.3 similar to ribosomal protein L27 MKLN1 7q32 muskelin 1, intracellular mediator containing kelch motifs PODXL 7q32-q33 podocalyxin-like LOC389557 7 hypothetical gene supported by BC029316; NM_021121 PLXNA4 7q32.3 plexin A4 DKFZp434G0625 7q32.3 hypothetical protein DKFZp434G0625 FLJ40288 7q32.3 hypothetical protein FLJ40288 FLJ20420
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5911 55.4 526 high endothelial venules (PMID: 9625756) expressed abundantly in the epithelial cells of kidney glomeruli (PMID: 18456258) - 9625756
    9 - 6007 - 558 high endothelial venules (PMID: 9625756) expressed abundantly in the epithelial cells of kidney glomeruli (PMID: 18456258) - 9625756
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
     vessel     Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Nervousbrain   lowly Homo sapiens
    Reproductivefemale systemplacenta  moderately Homo sapiens
    Respiratorylung   moderately Homo sapiens
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
     kidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte Homo sapiens
    Blood/Hematopoieticplatelet Homo sapiens
    Cardiovascularendothelial cell Homo sapiens
    Nervousneuron Homo sapiens
    Urinaryepithelial cell Homo sapiens
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines testicular tumor cell lines
    fluid/secretion
    at STAGE
    Text widely expressed in neurons during neural development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • single membrane-spanning region
  • extracellular multiple potential sites for N and O-linked glycosylation and four cysteines
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Podxl, Mus musculus
    ortholog to PODXL, Pan troglodytes
    ortholog to podxl, Danio rerio
    ortholog to Podxl, Rattus norvegicus
    Homologene
    FAMILY
  • sialomucin protein family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • functioning as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion
  • enhances the adherence of cells to immobilized ligands and to vascular endothelial cells through a mechanism dependent on the activity of integrins
  • potentially playing a role in cell migration and cell-cell recognition during brain development
  • in pluripotent stem cells and in cancer disease, may function in part to regulate and maintain the cell surface expression of SLC2A3
  • may function in part to regulate and maintain the cell surface expression of the glucose-3-transporter
  • renal polysialylated-containing protein that has been reported to function as an anti-adhesin in kidney podocytes
  • second highly sialylated neural adhesion protein, playing multiple roles in neural development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • integral constituent of the glomerular epithelial cell glycocalyx
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recombinant L-selectin and the HEV-specific monoclonal antibody MECA-79
  • linked to ezrin and the actin cytoskeleton via Na(+)/H(+)-exchanger regulatory factor, 2 NHERF2
  • actin filaments in podocytes mediated by CTTN and alteration of this interaction may play a role in the process of morphological change of podocytes
  • glucose-3-transporter (SLC2A3) and the cell-adhesion protein PODXL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to prostate cancer with tumor aggressiveness
    Variant & Polymorphism other variant 340A increasing the risk of prostate cancer with tumor aggressiveness
    Candidate gene
    Marker useful prognostic marker for astrocytic tumors
    Therapy target
    ANIMAL & CELL MODELS
  • transient knockdown of PODXL or the expression of PODXL lacking the cytosolic carboxyterminal domain (PODXL-Delta(451)) inhibited cell adherence
  • siRNA podocalyxin-knockdown experiments show decreased expression levels of the glucose-3-transporter