basic FUNCTION
| functioning as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion |
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extensively O& |
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8208;linked glycosylated glycoprotein |
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enhances the adherence of cells to immobilized ligands and to vascular endothelial cells through a mechanism dependent on the activity of integrins |
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is essential for maintaining the elaborate structure of kidney podocytes ( |
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potentially playing a role in cell migration and cell-cell recognition during brain development |
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in pluripotent stem cells and in cancer disease, may function in part to regulate and maintain the cell surface expression of SLC2A3 |
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may function in part to regulate and maintain the cell surface expression of the glucose-3-transporter |
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renal polysialylated-containing protein that has been reported to function as an anti-adhesin in kidney podocytes |
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second highly sialylated neural adhesion protein, playing multiple roles in neural development |
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integrity of the PODXL ectodomain is essential for enhancing cell adhesion but not migration, while the integrity of the cytoplasmic domain is required for both adhesion and migration |
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in endothelial cells, podocalyxin plays a previously unrecognized role in maintaining vascular integrity, likely through orchestrating interactions with extracellular matrix components and basement membrane |
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new function of PODXL expressed on tumor cells as an immunomodulatory molecule, which may represent a mechanism to evade the immune response |
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potential role of PODXL in neural development |
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having roles in renal podocyte diaphragm slit development |
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is a novel keratan sulfate (KS) proteoglycan in undifferentiated human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) |
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specific functions for PODXL in maintaining endothelial barrier function |
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has a key role in promoting the appropriate endothelial morphogenesis required to form functional barriers |
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PODXL expression by CNS tissue vascular endothelial cells (vECs) is essential for blood-brain barrier (BBB) maintenance under inflammatory conditions |
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role for PODXL in mature B-cell non-Hodgkin lymphoma (B-NHL) cell proliferation, survival, migration, drug resistance, and metabolic reprogramming |