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FLASH GENE
Symbol PODXL contributors: mct/shn - updated : 30-03-2020
HGNC name podocalyxin-like
HGNC id 9171
ASSOCIATED DISORDERS
corresponding disease(s) ARJPK1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast cancer cells might promote metastasis by disrupting cell adhesion, particularly during apical membrane expansion
constitutional germinal mutation     loss of function
lead to adult-onset focal segmental glomerulosclerosis (FSGS)
constitutional     --over  
significantly increased in preeclampsia at disease presentation
tumoral     --over  
in prostate cancer
constitutional germinal mutation     loss of function
patient presenting with congenital nephrotic syndrome, omphalocele and microcoria
Susceptibility to prostate cancer with tumor aggressiveness
Variant & Polymorphism other variant 340A increasing the risk of prostate cancer with tumor aggressiveness
Candidate gene
Marker
  • useful prognostic marker for astrocytic tumors
  • EZR, CLIC5 and PODXL could be likely biological markers to predict the prognosis of hepatocellular carcinoma (HCC) and these proteins participate in migration and invasion processes
  • putative immunohistochemical marker of prostate cancer that may contribute to stratification of patients for optimal treatment
  • Therapy target
    ANIMAL & CELL MODELS
  • transient knockdown of PODXL or the expression of PODXL lacking the cytosolic carboxyterminal domain (PODXL-Delta(451)) inhibited cell adherence
  • siRNA podocalyxin-knockdown experiments show decreased expression levels of the glucose-3-transporter