Symbol
| PODXL
| contributors: mct/shn - updated : 30-03-2020
|
HGNC name
| podocalyxin-like
|
HGNC id
| 9171
|
corresponding disease(s)
|
ARJPK1
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in breast cancer cells might promote metastasis by disrupting cell adhesion, particularly during apical membrane expansion | constitutional
| germinal mutation
|  
|  
| loss of function
|
lead to adult-onset focal segmental glomerulosclerosis (FSGS) | constitutional
|  
|  
| --over
|  
|
significantly increased in preeclampsia at disease presentation | tumoral
|  
|  
| --over
|  
|
in prostate cancer | constitutional
| germinal mutation
|  
|  
| loss of function
|
patient presenting with congenital nephrotic syndrome, omphalocele and microcoria | |
Susceptibility
|
to prostate cancer with tumor aggressiveness |
Variant & Polymorphism
other
| variant 340A increasing the risk of prostate cancer with tumor aggressiveness |
|
|
Candidate gene
Marker
| useful prognostic marker for astrocytic tumors | |
EZR, CLIC5 and PODXL could be likely biological markers to predict the prognosis of hepatocellular carcinoma (HCC) and these proteins participate in migration and invasion processes | |
putative immunohistochemical marker of prostate cancer that may contribute to stratification of patients for optimal treatment | Therapy target
| | |
| transient knockdown of PODXL or the expression of PODXL lacking the cytosolic carboxyterminal domain (PODXL-Delta(451)) inhibited cell adherence | |
siRNA podocalyxin-knockdown experiments show decreased expression levels of the glucose-3-transporter |