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FLASH GENE
Symbol PLAU contributors: mct - updated : 12-06-2013
HGNC name plasminogen activator, urokinase
HGNC id 9052
Location 10q22.2      Physical location : 75.670.861 - 75.677.256
Synonym name
  • urokinase-type plasminogen activator
  • Synonym symbol(s) UPA, URK, ATF, QPD, UPA, URK, u-PA, BDPLT5
    EC.number 3.4.21.73
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text NFKBL embedded in PLAU promoter region
    STRUCTURE 6.40 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - PLAU - HOX11 - qter
    Authors Stein (93)
    Physical map
    ANXA7 10q21.1-q21.2 annexin A7 ZMYND17 10q22.3 zinc finger, MYND domain containing 17 PPP3CB 10q22.3 protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) C10orf29 MYOZ1 10q22.1 myozenin 1 SYNPO2L 10q22.3 synaptopodin 2-like LOC118704 10q22.3 similar to ARF GTPase-activating protein LOC389978 10 similar to Ribosome biogenesis protein BMS1 homolog GLUDP3 10q22.1 glutamate dehydrogenase pseudogene 3 SEC24C 10q22.3 SEC24 related gene family, member C (S. cerevisiae) FUT11 10q22.3 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) LOC118487 10q22.3 similar to RIKEN cDNA 1110001O19 LOC196752 10q22.3 similar to CG32542-PA KIAA0913 10q22.3 KIAA0913 protein NDST2 10q22 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 CAMK2G 10q22.3 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma PLAU 10q23.3-q24.3 plasminogen activator, urokinase VCL 10q22.1-q23 vinculin AP3M1 10q22.3 adaptor-related protein complex 3, mu 1 subunit ADK 10q22.3 adenosine kinase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2680 - 414 - 2000 10824110
    11 - 2395 - 431 - 2000 10824110
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas   highly
    Nervousbrain    
    Respiratorylung   highly
     respiratory tractlarynx   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion urine
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cysteine-rich kringle domain
  • one EGF-like domain
  • HOMOLOGY
    Homologene
    FAMILY peptidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • plasminogen activator, urokinase serine protease, involved in plasminogen activation to plasmin
  • playing a role in the regulation of monocyte/macrophage functions, such as that occurring in inflammatory reactions
  • critical role for PLAU in Treg suppressor function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SP100 interacts with the ETS1 transcription factor, reduces ETS1-DNA binding and inhibits ETS1 transcriptional activity on the MMP1 and PLAU promoters
  • SERPINB2 is a potent inhibitor of urokinase-type plasminogen activator (PLAU) and also acts as a multifunctional protein
  • BRMS1 recruits HDAC1 to the NF-kappaB binding site of the PLAU promoter, modulates histone acetylation of RELA on the PLAU promoter, leading to reduced NF-kappaB binding activity on its consensus sequence, and reduced transactivation of PLAU expression
  • mediates Treg suppressor function via STAT5 and ERK signaling pathways
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Alzheimer disease
  • to myocardial infarction (MI)
  • Variant & Polymorphism other
  • polymorphism increasing the risk of Alzheimer disease
  • rs4065 might be a previously unknown genetic risk factor for MI
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS