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FLASH GENE
Symbol PLA2G4D contributors: - updated : 28-10-2005
HGNC name phospholipase A2, group IVD (cytosolic)
HGNC id 30038
Location 15q13-q15.1      Physical location : 42.359.881 - 42.386.752
Synonym name
  • phospholipase A2 delta, cytosolic
  • phospholipase A2, group IVD
    • Synonym symbol(s) cPLA2delta
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix  
     male systemprostate   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum corneum 
    Epithelialbarrier liningepidermisstratum spinosum 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal C2 domain, mediating the regulation by its association with lipid membranes
    • HOMOLOGY
    Homologene
    FAMILY type IV cytosolic phospholipase A(2) (cPLA(2)) family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text translocates to membrane vesicles in a calcium-dependent fashion
    basic FUNCTION
  • implicated in the initiation of the inflammatory response
  • may play a critical role in inflammation in psoriatic lesions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in psoriasis
    Susceptibility to atopic dermatitis and mycosis fungoides
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS