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FLASH GENE
Symbol PLA2G4D contributors: - updated : 28-10-2005
HGNC name phospholipase A2, group IVD (cytosolic)
HGNC id 30038
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix  
 male systemprostate   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermisstratum corneum 
Epithelialbarrier liningepidermisstratum spinosum 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal C2 domain, mediating the regulation by its association with lipid membranes
  • HOMOLOGY
    Homologene
    FAMILY type IV cytosolic phospholipase A(2) (cPLA(2)) family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text translocates to membrane vesicles in a calcium-dependent fashion
    basic FUNCTION
  • implicated in the initiation of the inflammatory response
  • may play a critical role in inflammation in psoriatic lesions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in psoriasis
    Susceptibility to atopic dermatitis and mycosis fungoides
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS