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FLASH GENE
Symbol PLA2G4D contributors: - updated : 28-10-2005
HGNC name phospholipase A2, group IVD (cytosolic)
HGNC id 30038
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal C2 domain, mediating the regulation by its association with lipid membranes
  • HOMOLOGY
    Homologene
    FAMILY type IV cytosolic phospholipase A(2) (cPLA(2)) family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text translocates to membrane vesicles in a calcium-dependent fashion
    basic FUNCTION
  • implicated in the initiation of the inflammatory response
  • may play a critical role in inflammation in psoriatic lesions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in psoriasis
    Susceptibility to atopic dermatitis and mycosis fungoides
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS