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Symbol PEPD contributors: npt/SGE - updated : 02-02-2010
HGNC name peptidase D
HGNC id 8840
Corresponding disease
PEPD prolidase deficiency
Location 19q13.11      Physical location : 33.877.854 - 34.012.799
Synonym name
  • prolidase
  • X-Pro dipeptidase
  • imidodipeptidase
  • proline dipeptidase
  • aminoacyl-L-proline hydrolase
  • Synonym symbol(s) PROLIDASE, MGC10905, PRD
    TYPE functioning gene
    STRUCTURE 134.94 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC147941 19q13.12 hypothetical LOC147941 LOC147942 19q13.12 hypothetical LOC147942 LOC388530 19 LOC388530 ZNF507 19q13.12 zinc finger protein 507 LOC147991 19q13.12 hypothetical protein LOC147991 DKFZP434L0718 PDCD5 19q13.1 programmed cell death 5 LOC388531 19 similar to regulator of G protein signaling 9-binding protein; RGS9-1 anchor; RGS9 anchor protein LOC390916 19 similar to RP2 protein, testosterone-regulated - ricefield mouse (Mus caroli) FLJ13072 19q13.12 hypothetical gene FLJ13072 SLC7A9 19q13.1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 FLJ14640 19q13.12 hypothetical protein FLJ14640 MGC32020 19q13.12 hypothetical protein MGC32020 RHPN2 19q13.12 rhophilin, Rho GTPase binding protein 2 ECGP 19q13.12 evolutionarily conserved G-patch domain containing LOC126248 19q13.12 hypothetical protein LOC126248 LRP3 19q12-q13.2 low density lipoprotein receptor-related protein 3 SLC7A10 19q12-q13.1 solute carrier family 7, (cationic amino acid transporter, y+ system) member 10 CEBPA 19q13.1 CCAAT/enhancer binding protein (C/EBP), alpha FLJ12355 19q13.12 hypothetical protein FLJ12355 LOC126242 19q13.12 similar to Aldose reductase (AR) (Aldehyde reductase) CEBPG 19q13.12 CCAAT/enhancer binding protein (C/EBP), gamma PEPD 19q13.1 peptidase D LOC388532 19 similar to 60S ribosomal protein L21 CHST8 19q13.1 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 KCTD15 19q13.12 potassium channel tetramerisation domain containing 15 LOC390917 19 similar to ribosomal protein S4 LOC126235 19q13.12 similar to ribosomal protein S4, X-linked LOC390918 19 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein DKFZP434D1335 KIAA0355 19q13.12 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein GPI 19q13.1 glucose phosphate isomerase MGC13096 19q13.12 hypothetical protein MGC13096 UBA2 9q12 hypothetical protein MGC13096 LOC126374 19q13.12 similar to LIM domains containing 1 LOC390919 19 similar to ZNF140-like transcription factor LOC390920 19 similar to zinc finger protein 2 ZNF302 19q13.2 zinc finger protein 302 LOC390921 19 similar to Major allergen I polypeptide chain 1 major form precursor (Allergen Fel d 1-A) (Fel d I-A) (Allergen Cat-1) (Fel dI) (AG4) ZNF181 19q13.1-q13.3 zinc finger protein 181 (HHZ181) FLJ30663 19q13.13 hypothetical protein FLJ30663 LOC390922 19 similar to FLJ38451 protein LOC390923 19 similar to zinc finger protein 113 LOC342885 19q13.13 similar to ABO histo-blood group B transferase DKFZp686N19164 FLJ38451 19q13.13 FLJ38451 protein KIAA1533 19q13.13 KIAA1533
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2019 - 493 - -
    - - 1896 - 452 - -
    - - 1827 - 429 - -
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     stomach   highly
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  moderately
     female systemuteruscervix moderately
    Skin/Tegumentskin   moderately
    Urinarybladder   moderately
     kidney   predominantly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    at STAGE
    physiological period pregnancy
    Text placenta
    conjugated PhosphoP , MetalloP , Other
    mono polymer homomer , dimer
    interspecies homolog to rattus Pepd (89.2pc)
    homolog to murine Pepd (88.6pc)
  • peptidase M24B family
  • eukaryotic-type prolidase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • homodimer that hydrolyzes dipetptides or tripeptides with a prolyl or hydroxyprolyl residue in the C-terminal position
  • playing an important role in collagen metabolism (high level of iminoacids in collagen), may be rate limiting for the production of collagen
  • acting as a metallocarboxypeptidase D
  • may have a role in angiogenic signalling, because of its overexpression increasing HIF1A (Surazynski 2008)
    metabolism aminoacid , other
    collagen catabolism
    a component
  • acetylation
    small molecule metal binding,
  • Mn2+ (2 ions per subunit)
  • protein
    cell & other
    corresponding disease(s) PEPD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    increased serum prolidase activity may be associated with endometrial cancer and may be related to local invasion of endometrial cancer (Arioz 2009)
    Variant & Polymorphism
    Candidate gene
  • serum prolidase activity can accurately predict the degree and stage of all histological lesions in non-alcoholic fatty liver disease (Kayadibi 2009)
  • serum prolidase activity is significantly associated with the presence and severity of coronary artery disease and elevated activity might be an independent predictor of coronary atherosclerosis (Yildiz 2008)
  • the presence of atrial fibrillation in patients with severe mitral stenosis may be associated with the plasma prolidase activity, tissue and plasma oxidative parameters (Rabus 2008)
  • an elevated pleural fluid and serum prolidase activity in patients with tuberculous (TB) pleurisy compared with non-TB pleurisy group (Ipcioglu 2008)
  • serum prolidase activity is associated with the presence hypertension independent of left ventricular hypertrophy (Demirbag 2007)
  • Marker
    Therapy target