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FLASH GENE
Symbol PEPD contributors: npt/SGE - updated : 02-02-2010
HGNC name peptidase D
HGNC id 8840
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP , MetalloP , Other
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to rattus Pepd (89.2pc)
homolog to murine Pepd (88.6pc)
Homologene
FAMILY
  • peptidase M24B family
  • eukaryotic-type prolidase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • homodimer that hydrolyzes dipetptides or tripeptides with a prolyl or hydroxyprolyl residue in the C-terminal position
  • playing an important role in collagen metabolism (high level of iminoacids in collagen), may be rate limiting for the production of collagen
  • acting as a metallocarboxypeptidase D
  • may have a role in angiogenic signalling, because of its overexpression increasing HIF1A (Surazynski 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid , other
    signaling
    collagen catabolism
    a component
  • acetylation
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mn2+ (2 ions per subunit)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PEPD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    increased serum prolidase activity may be associated with endometrial cancer and may be related to local invasion of endometrial cancer (Arioz 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • serum prolidase activity can accurately predict the degree and stage of all histological lesions in non-alcoholic fatty liver disease (Kayadibi 2009)
  • serum prolidase activity is significantly associated with the presence and severity of coronary artery disease and elevated activity might be an independent predictor of coronary atherosclerosis (Yildiz 2008)
  • the presence of atrial fibrillation in patients with severe mitral stenosis may be associated with the plasma prolidase activity, tissue and plasma oxidative parameters (Rabus 2008)
  • an elevated pleural fluid and serum prolidase activity in patients with tuberculous (TB) pleurisy compared with non-TB pleurisy group (Ipcioglu 2008)
  • serum prolidase activity is associated with the presence hypertension independent of left ventricular hypertrophy (Demirbag 2007)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS