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FLASH GENE
Symbol PDYN contributors: np/ - updated : 19-12-2007
HGNC name prodynorphin
HGNC id 8820
Corresponding disease
SCA23 spinocerebellar ataxia 23
Location 20p13      Physical location : 1.959.402 - 1.974.891
Synonym name
  • enkephalin B
  • beta-neoendorphin-dynorphin
  • leu-enkephalin
  • leumorphin
  • preproenkephalin B
  • rimorphin
    • Synonym symbol(s) NDDB, MGC26418, PENKB
    DNA
    TYPE functioning gene
    STRUCTURE 15.49 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    motif repetitive sequence
    text structure one to four repeats of a 68 bp element containing one binding site per repeat for the transcription factor Ap1
    MAPPING cloned Y linked Y status provisional
    Map see OXT
    Physical map
    PSMF1 20p13-p12.2 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) ACTGP3 20p13 actin, gamma pseudogene 3 C20orf46 20p13 chromosome 20 open reading frame 46 SNPH 20p13 syntaphilin SDCBP2 20p13 syndecan binding protein (syntenin) 2 FLJ20802 20p13 hypothetical protein FLJ20802 FKBP1A 20p13 FK506 binding protein 1A, 12kDa NSFL1C 20p13 NSFL1 (p97) cofactor (p47) PTPNS1L3 20p12.2-13 protein tyrosine phosphatase, non-receptor type substrate 1-like 3 PTPNS1L2 20p13 protein tyrosine phosphatase, non-receptor type substrate 1-like 2 SIRPB1 20p13 signal-regulatory protein beta 1 SIRPB2 20p13 signal-regulatory protein beta 2 LOC391227 20 similar to Signal-regulatory protein beta-2 precursor (SIRP-beta-2) (SIRP-b2) LOC388779 20 LOC388779 PTPNS1 20p13 protein tyrosine phosphatase, non-receptor type substrate 1 PDYN 20p13 prodynorphin RPL7P2 20p13 ribosomal protein L7 pseudogene 2 STK35 20 serine/threonine kinase 35 LOC388780 20 LOC388780 TGM3 20p13 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) TGM6 20p13 transglutaminase y SNRPB 20p13 small nuclear ribonucleoprotein polypeptides B and B1 MGC10715 20p13 novel C2H2 type zinc finger protein TMC2 20p13 transmembrane, cochlear expressed, 2 NOL5A 20p13 nucleolar protein 5A (56kDa with KKE/D repeat) IDH3B 20p13 isocitrate dehydrogenase 3 (NAD+) beta KIAA1442 20p13 KIAA1442 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2487 - 254 - -
    4 - 2760 - 254 - 2007 16914231
    3 - 2541 - 254 - -
    4 - 2743 - 254 - -
    3 - 2588 - 254 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum highly Homo sapiens
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal six conserved cysteines
    • HOMOLOGY
    interspecies homolog to murine Pdyn
    Homologene
    FAMILY
  • opioids neuropeptides precursors family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text translocation across the plasma membrane may represent a previously unknown mechanism by which dynorphins can signal information to the cell interior
    basic FUNCTION
  • playing a role in Alzheimer disease neuropathology
  • induces calcium influx via voltage-sensitive calcium channels in sensory neurons by activating bradykinin receptors
  • activates bradykinin receptors to maintain neuropathic pain
  • regulate pain processing and modulate the rewarding effects of addictive substances
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA23
    Susceptibility to alcohol dependence
    Variant & Polymorphism repeat , other
  • allelic variation at the promoter contributing to prtection against cocaine dependence
  • polymorphisms increasing alcohol dependence
    • Candidate gene
    Marker
    Therapy target mechanism for endogenous dynorphin to promote pain through its agonist action at bradykinin receptors and suggest new avenues for therapeutic intervention
    ANIMAL & CELL MODELS