Citations for
1PDYN, REST
PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain.
Henriksson R, Bäckman CM, Harvey BK, Kadyrova H, Bazov I, Shippenberg TS, Bakalkin G.
Biochim Biophys Acta 1839(11):1226-32. doi: 10.1016/j.bbagrm.2014.09.001. Epub 2014 Sep 8. 2014
2ITCH, PDYN
Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord.
Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE.
Neuron 82(3):573-86. doi: 10.1016/j.neuron.2014.02.046. Epub 2014 Apr 10. 2014
3PDYN
Possible role of dynorphins in Alzheimer's disease and age-related cognitive deficits.
Ménard C, Herzog H, Schwarzer C, Quirion R.
Neurodegener Dis 13(2-3):82-5. doi: 10.1159/000353848. Epub 2013 Aug 22. 2014
4OPRK1, PDYN
Direct detection of neuropeptide dynorphin A binding to the second extracellular loop of the κ opioid receptor using a soluble protein scaffold.
Björnerås J, Kurnik M, Oliveberg M, Gräslund A, Mäler L, Danielsson J.
FEBS J 281(3):814-24. 2014
5PDYN, SCA23
Identification and characterization of novel PDYN mutations in dominant cerebellar ataxia cases.
Jezierska J, Stevanin G, Watanabe H, Fokkens MR, Zagnoli F, Kok J, Goas JY, Bertrand P, Robin C, Brice A, Bakalkin G, Durr A, Verbeek DS.
J Neurol 260(7):1807-12. doi: 10.1007/s00415-013-6882-6. Epub 2013 Mar 8. 2013
6PDYN, SCA23
The frequency of spinocerebellar ataxia type 23 in a UK population.
Fawcett K, Mehrabian M, Liu YT, Hamed S, Elahi E, Revesz T, Koutsis G, Herscheson J, Schottlaender L, Wardle M, Morrison PJ, Morris HR, Giunti P, Wood N, Houlden H.
J Neurol 260(3):856-9. doi: 10.1007/s00415-012-6721-1. Epub 2012 Oct 30. Erratum in: J Neurol. 2013 Mar;260(3):860. 2013
7PDYN
Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction.
Clarke TK, Ambrose-Lanci L, Ferraro TN, Berrettini WH, Kampman KM, Dackis CA, Pettinati HM, O'Brien CP, Oslin DW, Lohoff FW.
Genes Brain Behav 11(4):415-23. doi: 10.1111/j.1601-183X.2012.00785.x. Epub 2012 Apr 11. 2012
8PDYN
Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.
Taqi MM, Bazov I, Watanabe H, Sheedy D, Harper C, Alkass K, Druid H, Wentzel P, Nyberg F, Yakovleva T, Bakalkin G.
Addict Biol 16(3):499-509. doi: 10.1111/j.1369-1600.2011.00323.x. Epub 2011 Apr 26. 2011
9PDYN, SCA23
Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23.
Bakalkin G, Watanabe H, Jezierska J, Depoorter C, Verschuuren-Bemelmans C, Bazov I, Artemenko KA, Yakovleva T, Dooijes D, Van de Warrenburg BP, Zubarev RA, Kremer B, Knapp PE, Hauser KF, Wijmenga C, Nyberg F, Sinke RJ, Verbeek DS.
Am J Hum Genet 87(5):593-603. Epub 2010 Oct 28. Erratum in: Am J Hum Genet. 2010 Nov 12;87(5):736. PMID: 21035104 2010
10PDYN, PENK
Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity.
Gieryk A, Ziolkowska B, Solecki W, Kubik J, Przewlocki R.
Psychopharmacology (Berl) 208(2):291-300. doi: 10.1007/s00213-009-1730-1. Epub 2009 Dec 9. 2010
11PDYN
Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.
Pirker S, Gasser E, Czech T, Baumgartner C, Schuh E, Feucht M, Novak K, Zimprich F, Sperk G.
Hippocampus 19(11):1051-4. doi: 10.1002/hipo.20633. 2009
12PDYN
Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis.
Kauffman MA, Consalvo D, Gonzalez MD, Kochen S.
Dis Markers 24(3):135-40. 2008
13PDYN
Dysregulation of dynorphins in Alzheimer disease.
Yakovleva T, Marinova Z, Kuzmin A, Seidah NG, Haroutunian V, Terenius L, Bakalkin G.
Neurobiol Aging 28(11):1700-8. Epub 2006 Aug 17. 2007
14PDYN
Association of the kappa-opioid system with alcohol dependence.
Xuei X, Dick D, Flury-Wetherill L, Tian HJ, Agrawal A, Bierut L, Goate A, Bucholz K, Schuckit M, Nurnberger J Jr, Tischfield J, Kuperman S, Porjesz B, Begleiter H, Foroud T, Edenberg HJ.
Mol Psychiatry 11(11):1016-24. Epub 2006 Aug 22. 2006
15PDYN
Dynorphin A activates bradykinin receptors to maintain neuropathic pain.
Lai J, Luo MC, Chen Q, Ma S, Gardell LR, Ossipov MH, Porreca F.
Nat Neurosci 9(12):1534-40. Epub 2006 Nov 19. 2006
16PDYN
Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence.
Dahl JP, Weller AE, Kampman KM, Oslin DW, Lohoff FW, Ferraro TN, O'Brien CP, Berrettini WH.
Am J Med Genet B Neuropsychiatr Genet 139(1):106-8. 2005
17PDYN
Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission.
Marinova Z, Vukojevic V, Surcheva S, Yakovleva T, Cebers G, Pasikova N, Usynin I, Hugonin L, Fang W, Hallberg M, Hirschberg D, Bergman T, Langel U, Hauser KF, Pramanik A, Aldrich JV, GrŠslund A, Terenius L, Bakalkin G.
J Biol Chem 280(28):26360-70. Epub 2005 May 13. 2005
18PDYN
Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse.
Chen AC, LaForge KS, Ho A, McHugh PF, Kellogg S, Bell K, Schluger RP, Leal SM, Kreek MJ.
Am J Med Genet 114(4):429-35. 2002
19PDYN, PENK
Chromosomal localization of the human proenkephalin and prodynorphin genes.
Litt M, et al.
Am J Hum Genet 42 : 327-334. 1988