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FLASH GENE
Symbol OXT contributors: mct/npt - updated : 18-01-2014
HGNC name oxytocin, prepropeptide
HGNC id 8528
Location 20p13      Physical location : 3.052.265 - 3.053.162
Synonym name
  • neurophysin I
  • oxytocin-neurophysin I
  • oxytocin, prepro- (neurophysin I)
  • Synonym symbol(s) OT, OT-NPI, MGC126890, MGC126892
    DNA
    TYPE functioning gene
    STRUCTURE 0.89 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map pter - AVP /OXT , PDYN - D20S5 , D20S6 - cen
    Physical map
    NOL5A 20p13 nucleolar protein 5A (56kDa with KKE/D repeat) IDH3B 20p13 isocitrate dehydrogenase 3 (NAD+) beta KIAA1442 20p13 KIAA1442 protein RPL19P1 20p13 ribosomal protein L19 pseudogene 1 CPXM 20p12.3-p13 carboxypeptidase X (M14 family) C20orf141 20p13 chromosome 20 open reading frame 141 LOC388781 20 similar to RIKEN cDNA 4933425O20 C20orf81 20p13 chromosome 20 open reading frame 81 VPS16 20p13-p12 vacuolar protein sorting 16 (yeast) PTPRA 20p13 protein tyrosine phosphatase, receptor type, A GNRH2 20p13 gonadotropin-releasing hormone 2 MRPS26 20p13 mitochondrial ribosomal protein S26 OXT 20p13 oxytocin, prepro- (neurophysin I) AVP 20p13 arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) UBCE7IP5 20p13 likely ortholog of mouse ubiquitin conjugating enzyme 7 interacting protein 5 FLJ13149 20p13 hypothetical protein FLJ13149 ProSAPiP1 20p13 ProSAPiP1 protein C20orf116 20p13 chromosome 20 open reading frame 116 ITPA 20p inosine triphosphatase (nucleoside triphosphate pyrophosphatase) SLC4A11 20p12 solute carrier family 4, sodium bicarbonate transporter-like, member 11 C20orf194 20p13 chromosome 20 open reading frame 194 UBE2V1P1 20p13 ubiquitin-conjugating enzyme E2 variant 1 pseudogene 1 ATRN 20p13 attractin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 512 12.7 125 - 2011 21315262
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine     Homo sapiens
    Nervousbraindiencephalonhypothalamus   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Oxt
    homolog to C..elegans F17C11.2
    Homologene
    FAMILY
  • vasopressin/oxytocin family
  • CATEGORY signaling hormone , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • contracting smooth muscle during parturition and lactation
  • involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour as well as in the regulation of water excretion and cardiovascular functions
  • modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels
  • anabolic regulator of bone mass, with potential implications for osteoporosis therapy
  • can facilitate amygdala-dependent, socially reinforced learning and emotional empathy in men
  • potentially acting as a carbohydrate-specific inhibitor of feeding
  • primitive neurohypophyseal hormone that plays a primary and indispensible role in mammalian lactation
  • OXT produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action
  • can act as a neurotransmitter that reduces anxiety, promotes social behaviors and regulates food intake
  • OXT could be essential for the normal development of the serotoninergic system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text carrier protein neurophysin I
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    posterior pituitary hormone oxytocin
    a component
  • neurophysin 1 binding specifically to oxytocin which are two proteins encoded by the same gene
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neurophysin 1 binding specifically to oxytocin
  • interacting with SYT4 (SYT4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of SYT4 and thus enhanced negative regulation of oxytocin release)
  • relationship between FTO and OXT could thus be an important mechanism through which FTO exerts its effect on energy balance
  • GNAI2 plays an essential role in OXT and EGF signaling to induce prostate cancer cell migration
  • cell & other
    REGULATION
    repressed by SYT4 (negative regulation of SYT4 on oxytocin release represents a hypothalamic basis of neuropeptide exocytosis in controlling obesity and related diseases)
    Other activated while it is being transported along the axon to the posterior pituitary
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS